Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases

Thivierge, Karine, Mathew, Rency T., Nsangou, Desire M. M., Da Silva, Fabio, Cotton, Sophie, Skinner-Adams, Tina S., Trenholme, Katharine R., Brown, Christopher L., Stack, Colin M., Gardiner, Donald L. and Dalton, John P. (2012) Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases. Arkivoc, 2012 4: 330-346. doi:10.3998/ark.5550190.0013.424


Author Thivierge, Karine
Mathew, Rency T.
Nsangou, Desire M. M.
Da Silva, Fabio
Cotton, Sophie
Skinner-Adams, Tina S.
Trenholme, Katharine R.
Brown, Christopher L.
Stack, Colin M.
Gardiner, Donald L.
Dalton, John P.
Title Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidases
Journal name Arkivoc   Check publisher's open access policy
ISSN 1551-7012
1551-7004
Publication date 2012-06-25
Sub-type Article (original research)
DOI 10.3998/ark.5550190.0013.424
Open Access Status DOI
Volume 2012
Issue 4
Start page 330
End page 346
Total pages 17
Publisher Arkat Usa
Language eng
Abstract The M1 alanyl aminopeptidase and M17 leucyl aminopeptidase are critical to the growth and development of malaria parasites inside host erythrocytes. Potent aminopeptidase inhibitors kill malaria parasites in culture and are also active in vivo against murine malaria. Functional recombinant enzyme studies have been used to decipher the three-dimensional structures of both enzymes that together with new and specific inhibitors are facilitating structure-activity- relationship (SAR) and functional studies. Here we review the progress made in our knowledge of these two enzymes which is bringing them closer to being validated anti-malarial drug targets.
Keyword Aminopeptidases
Anti-malarials
Enzymes
Malaria
Peptidases
Plasmodium
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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