AKT-independent PI3-K signaling in cancer - Emerging role for SGK3

Bruhn, Maressa A, Pearson, Richard B, Hannan, Ross D and Sheppard, Karen E (2013) AKT-independent PI3-K signaling in cancer - Emerging role for SGK3. Cancer Management and Research, 5 1: 281-292. doi:10.2147/CMAR.S35178


Author Bruhn, Maressa A
Pearson, Richard B
Hannan, Ross D
Sheppard, Karen E
Title AKT-independent PI3-K signaling in cancer - Emerging role for SGK3
Journal name Cancer Management and Research   Check publisher's open access policy
ISSN 1179-1322
Publication date 2013-08-24
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2147/CMAR.S35178
Open Access Status DOI
Volume 5
Issue 1
Start page 281
End page 292
Total pages 12
Place of publication Macclesfield, United Kingdom
Publisher Dove Medical Press
Collection year 2014
Abstract The phosphoinositide 3-kinase (PI3-K) signaling pathway plays an important role in a wide variety of fundamental cellular processes, largely mediated via protein kinase B/v-akt murine thymoma viral oncogene homolog (PKB/AKT) signaling. Given the crucial role of PI3-K/AKT signaling in regulating processes such as cell growth, proliferation, and survival, it is not surprising that components of this pathway are frequently dysregulated in cancer, making the AKT kinase family members important therapeutic targets. The large number of clinical trials currently evaluating PI3-K pathway inhibitors as a therapeutic strategy further emphasizes this. The serum- and glucocorticoid-inducible protein kinase (SGK) family is made up of three isoforms, SGK1, 2, and 3, that are PI3-K-dependent, serine/threonine kinases, with similar substrate specificity to AKT. Consequently, the SGK family also regulates similar cell processes to the AKT kinases, including cell proliferation and survival. Importantly, there is emerging evidence demonstrating that SGK3 plays a critical role in AKT-independent oncogenic signaling. This review will focus on the role of SGK3 as a key effector of AKT-independent PI3-K oncogenic signaling.
Keyword AKT
Cancer
MTOR
PI3-kinase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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