Aldosterone and Other Steroids

Funder, John W. (2007). Aldosterone and Other Steroids. In Gregory Y. H. Lip and John E. Hall (Ed.), Comprehensive Hypertension (pp. 291-297) Philadelphia, PA United States: Mosby Elsevier.

Author Funder, John W.
Title of chapter Aldosterone and Other Steroids
Title of book Comprehensive Hypertension
Place of Publication Philadelphia, PA United States
Publisher Mosby Elsevier
Publication Year 2007
Sub-type Research book chapter (original research)
ISBN 9780323039611
Editor Gregory Y. H. Lip
John E. Hall
Chapter number 26
Start page 291
End page 297
Total pages 7
Total chapters 98
Language eng
Formatted Abstract/Summary
For over 50 years aldosterone excess has been known to raise blood pressure in humans (Conn's syndrome), and over 60 years ago the combination of deoxycorticosterone and salt was shown to do so in experimental animals. In both instances renal sodium and water retention was inculpated as the initial effector mechanism, with the resultant increase in circulatory volume followed by an increased cardiac output, in turn normalized by elevation of blood pressure. Subsequently, steroids with predominantly glucocorticoid activity were also shown to raise blood pressure, an effect that was not blocked by spironolactone, thus presumably mediated via glucocorticoid rather than mineralocorticoid receptors, and which appears to be mediated by reduced nitric oxide availability.1 In experimental animals, administration of high levels of testosterone causes hypertension, by blockade of the adrenal enzyme (CYP11B1) needed for glucocorticoid production, causing elevation of ACTH and deoxycorticosterone levels.
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
Collection: Institute for Molecular Bioscience - Publications
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