Efficacy of high-dose vitamin d supplementation in the critically Ill patients

Perron, Rachel M. and Lee, Paul (2013) Efficacy of high-dose vitamin d supplementation in the critically Ill patients. Inflammation and Allergy - Drug Targets, 12 4: 273-281. doi:10.2174/18715281113129990047


Author Perron, Rachel M.
Lee, Paul
Title Efficacy of high-dose vitamin d supplementation in the critically Ill patients
Journal name Inflammation and Allergy - Drug Targets   Check publisher's open access policy
ISSN 1871-5281
2212-4055
Publication date 2013
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/18715281113129990047
Open Access Status
Volume 12
Issue 4
Start page 273
End page 281
Total pages 9
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers Ltd.
Collection year 2014
Language eng
Subject 2403 Immunology
2723 Immunology and Allergy
3004 Pharmacology
Abstract Vitamin D deficiency and its adverse skeletal sequelae are well recognized in the general population. Recent observation of high prevalence of low vitamin D states and their associations with worse clinical outcomes in critically ill populations have sparked interest in the role of supplementation for these patients. High-dose vitamin D efficaciously increases serum levels, but its impact on clinical outcome has not been examined. This article will review results from observational studies on prevalence and outcomes of hypovitaminosis D in critically ill patients, as well as caveats of vitamin D interventional trials. Improved understanding of vitamin D metabolism in critical illness will clarify the therapeutic potential of this pleiotropic hormone and facilitate implementation of cost-effective clinical trials.
Keyword Critical illness
Critically ill
High-dose supplementation
Hypovitaminosis d
Vitamin d
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Thu, 28 Nov 2013, 18:55:04 EST by System User on behalf of School of Medicine