Obesity and melanoma: exploring molecular links

Chen, Jiezhong, Chi, Mengna, Chen, Chen and Zhang, Xu Dong (2013) Obesity and melanoma: exploring molecular links. Journal of Cellular Biochemistry, 114 9: 1955-1961. doi:10.1002/jcb.24549

Author Chen, Jiezhong
Chi, Mengna
Chen, Chen
Zhang, Xu Dong
Title Obesity and melanoma: exploring molecular links
Journal name Journal of Cellular Biochemistry   Check publisher's open access policy
ISSN 0730-2312
Publication date 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/jcb.24549
Open Access Status
Volume 114
Issue 9
Start page 1955
End page 1961
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher Jossey Bass
Collection year 2014
Language eng
Abstract Obesity is now a major health problem due to its rapidly increasing incidence worldwide and severe consequences. Among many conditions associated with obesity are some cancers including melanoma. Both genetic defects and environmental risk factors are involved in the carcinogenesis of melanoma. Activation of multiple signal pathways such as the PI3K/Akt and MAPK pathways are necessary for the initiation of melanoma. Activation of the MAPK pathway as a result of activating mutations in BRAF is commonly seen in melanoma though it alone is not sufficient to cause malignant transformation of melanocytes. Obesity can result in the activation of many signal pathways including PI3K/Akt, MAPK, and STAT3. The activation of these pathways may have a synergistic effect with the genetic defects thereby increasing the incidence of melanoma.
Keyword MAPK
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
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