Controlling clostridium difficile

McFarlane, Mark and Hajkowicz, Krispin (2013) Controlling clostridium difficile. Australian Prescriber, 36 4: 121-124.

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Author McFarlane, Mark
Hajkowicz, Krispin
Title Controlling clostridium difficile
Journal name Australian Prescriber   Check publisher's open access policy
ISSN 0312-8008
Publication date 2013-08
Year available 2013
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 36
Issue 4
Start page 121
End page 124
Total pages 4
Place of publication Deakin, Australia
Publisher National Prescribing Service
Collection year 2014
Formatted abstract
Clostridium difficile infection causes colitis and is closely associated with the use of antimicrobials, probably due to disruption of the normal bowel flora.

Avoiding inappropriate antimicrobial use is the most important way to prevent this potentially life-threatening infection.

Emergent hypervirulent variants of C. difficile are associated with increased transmission, morbidity and mortality and have caused epidemics in North America and Europe. Cases have also been reported in Australia so intensified surveillance and antimicrobial stewardship is more important than ever.

While any antimicrobial can precipitate C. difficile, fluoroquinolones, clindamycin and cephalosporins are particularly implicated.

Other drugs, such as proton pump inhibitors, have also been associated with an increased incidence of C. difficile.

Severe disease is managed in hospital. For non-severe disease, treatment generally includes supportive measures and treatment with oral metronidazole. Relapse is common.
Keyword Antibiotics
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Thu, 28 Nov 2013, 17:59:27 EST by System User on behalf of School of Medicine