Iron and hepatic carcinogenesis

Tirnitz-Parker, Janina E. E., Glanfield, Amber, Olynyk, John K. and Ramm, Grant A. (2013) Iron and hepatic carcinogenesis. Critical Reviews in Oncogenesis, 18 5: 391-407. doi:10.1615/CritRevOncog.2013007759

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Author Tirnitz-Parker, Janina E. E.
Glanfield, Amber
Olynyk, John K.
Ramm, Grant A.
Title Iron and hepatic carcinogenesis
Journal name Critical Reviews in Oncogenesis   Check publisher's open access policy
ISSN 0893-9675
2162-6448
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1615/CritRevOncog.2013007759
Open Access Status
Volume 18
Issue 5
Start page 391
End page 407
Total pages 17
Place of publication Redding, CT, United States
Publisher Begell House
Collection year 2014
Language eng
Subject 1306 Cancer Research
Abstract Iron is an essential co-factor for life; however, a physiologically optimal balance is critical. Too much or too little iron can have detrimental effects on human health. In this article, we explore the relationships between iron and hepatocellular carcinoma (HCC). Iron can act as a modulating co-factor in a range of chronic liver diseases and can accelerate the development of liver injury, fibrosis, cirrhosis, and ultimately HCC. Iron can, however, also act as a sole factor in the causation of liver cirrhosis and HCC in individuals with hereditary hemochromatosis (HH). We overview the regulation of normal iron metabolism and the role of iron in wound healing and associated cell types as well as in pathophysiologies that predispose to HCC. We review how these injury processes are inextricably linked, providing a mechanistic basis for understanding how iron and hepatic injury potentially result in HCC.
Keyword Cirrhosis
Hepatic fibrosis
Hepatocellular carcinoma
Iron
Liver
Liver progenitor cell
Reactive oxygen species
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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