Reconsolidation and extinction of an appetitive pavlovian memory

Flavell, Charlotte R. and Lee, Jonathan L. C. (2013) Reconsolidation and extinction of an appetitive pavlovian memory. Neurobiology of Learning and Memory, 104 25-31. doi:10.1016/j.nlm.2013.04.009

Author Flavell, Charlotte R.
Lee, Jonathan L. C.
Title Reconsolidation and extinction of an appetitive pavlovian memory
Journal name Neurobiology of Learning and Memory   Check publisher's open access policy
ISSN 1074-7427
Publication date 2013
Sub-type Article (original research)
DOI 10.1016/j.nlm.2013.04.009
Open Access Status
Volume 104
Start page 25
End page 31
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2014
Abstract When memories are retrieved, they can enter a labile state during which the memory may be modified and subsequently restabilized through the process of reconsolidation. However, this does not occur in all situations, and certain "boundary conditions" determine whether a memory will undergo reconsolidation. Naïve male lister hooded rats were trained for 5days to press a lever in order to retrieve a food reward associated with a pavlovian light stimulus. Three days post-training, animals were injected with either MK-801 (0.1mgkg-1; i.p.) or saline vehicle, 30min before they were placed back into the training context for a retrieval session. Lever pressing was reinforced only by the light stimulus and was restricted to either 10, 30 or 50 presentations of the light conditioned stimulus. After 48h, animals were again returned to the boxes and light-reinforced lever-pressing activity was recorded. MK-801-treated animals in the 10CS group significantly reduced lever pressing at test, compared to saline controls. In contrast, MK-801-treated rats in the 50CS group demonstrated a significant increase. There was no effect of MK-801 in the 30CS group. Additionally, there were no effects of MK-801 in an analogous, pure instrumental, setting when the cue lights were omitted. The opposing effects of MK-801 under different parametric conditions likely reflect impairments of appetitive pavlovian memory reconsolidation and extinction, respectively. These results demonstrate a competition between reconsolidation and extinction. However, there are also conditions under which MK-801 fails to impair either process.
Keyword Food-seeking
NMDA receptor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
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