A randomized controlled clinical trial comparing a remineralizing paste with an antibacterial gel to prevent early childhood caries

Plonka, K. A., Pukallus, M. L., Holcombe, T. F., Barnett, A. G., Walsh, L. J. and Seow, W. K. (2013) A randomized controlled clinical trial comparing a remineralizing paste with an antibacterial gel to prevent early childhood caries. Pediatric Dentistry, 35 1: e8-e12.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Author Plonka, K. A.
Pukallus, M. L.
Holcombe, T. F.
Barnett, A. G.
Walsh, L. J.
Seow, W. K.
Title A randomized controlled clinical trial comparing a remineralizing paste with an antibacterial gel to prevent early childhood caries
Journal name Pediatric Dentistry   Check publisher's open access policy
ISSN 0164-1263
1942-5473
Publication date 2013
Sub-type Article (original research)
Volume 35
Issue 1
Start page e8
End page e12
Total pages 5
Place of publication Chicago, IL, United States
Publisher American Academy of Pediatric Dentistry
Collection year 2014
Subject 3500 Dentistry
Formatted abstract
Purpose: The purpose of this study was to compare twice daily tooth-brushing using 0.304 percent fluoride toothpaste alone with: (1) twice daily tooth-brushing plus once daily 10% casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste; and (2) twice daily tooth-brushing plus once daily 0.12% chlorhexidine gel (CHX) for reducing early childhood caries (ECC) and mutans streptococci (MS) colonization.

Methods: Subjects (n=622) recruited at birth were randomized to receive either CPP-ACP or CHX or no product (study control [SC]). All children were examined at 6, 12, and 18 months old in their homes, and at 24 months old in a community dental clinic.

Results: At 24 months old, the caries incidence was 1% (2/163) in CPP-ACP, 2% (4/180) in CHX, and 2% (3/188) in SC groups. In children who were previously MS colonized at 12 and 18 months old, 0% (0/11) and 5% (3/63), respectively, of the CPP-ACP group remained MS-positive versus 22% (2/9) and 72% (18/25) in CHX and 16% (4/25) and 50% (7/14) in SC groups (P<.001).

Conclusions: There is insufficient evidence to justify the daily use of casein phosphopeptide-amorphous calcium phosphate or chlorhexidine gel to control early childhood caries.
Keyword Casein phosphopeptide amorphous calcium phosphate
Chlorhexidine
Dental caries
Lactobacillus
Streptococcus Mutans
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Dentistry Publications
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 28 Nov 2013, 12:53:55 EST by System User on behalf of School of Dentistry