Structural diversity in conserved regions like the DRY-motif among viral 7TM receptors - A consequence of evolutionary pressure?

Jensen, Ann-Sofi Molleskov, Sparre-Ulrich, Alexander Hovard, Davis-Poynter, Nicholas and Rosenkilde, Mette Marie (2012) Structural diversity in conserved regions like the DRY-motif among viral 7TM receptors - A consequence of evolutionary pressure?. Advances in Virology, 2012 Article ID.231813: . doi:10.1155/2012/231813


Author Jensen, Ann-Sofi Molleskov
Sparre-Ulrich, Alexander Hovard
Davis-Poynter, Nicholas
Rosenkilde, Mette Marie
Title Structural diversity in conserved regions like the DRY-motif among viral 7TM receptors - A consequence of evolutionary pressure?
Journal name Advances in Virology   Check publisher's open access policy
ISSN 1687-8639
1687-8647
Publication date 2012
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1155/2012/231813
Open Access Status DOI
Volume 2012
Issue Article ID.231813
Total pages 15
Place of publication New York, NY United States
Publisher Hindawi Publishing Corporation
Collection year 2013
Language eng
Subject 2406 Virology
2725 Infectious Diseases
Abstract Several herpes- and poxviruses have captured chemokine receptors from their hosts and modified these to their own benefit. The human and viral chemokine receptors belong to class A 7 transmembrane (TM) receptors which are characterized by several structural motifs like the DRY-motif in TM3 and the C-terminal tail. In the DRY-motif, the arginine residue serves important purposes by being directly involved in G protein coupling. Interestingly, among the viral receptors there is a greater diversity in the DRY-motif compared to their endogenous receptor homologous. The C-terminal receptor tail constitutes another regulatory region that through a number of phosphorylation sites is involved in signaling, desensitization, and internalization. Also this region is more variable among virus-encoded 7TM receptors compared to human class A receptors. In this review we will focus on these two structural motifs and discuss their role in viral 7TM receptor signaling compared to their endogenous counterparts.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Clinical Medical Virology Centre Publications
 
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