Studies of lipid profile, liver function and kidney function parameters of rat plasma after chronic administration of "Sulavajrini Vatika"

Kundu, N. Krishna, Obayed, Ullah M., Hamid, Kaiser, Urmi, Kaniz Fatima, Bulbul, Israt Jahan, Khan, Muhammad Atikul Islam, Akter, Momita and Choudhuri, M. S. K. (2012) Studies of lipid profile, liver function and kidney function parameters of rat plasma after chronic administration of "Sulavajrini Vatika". Pakistan Journal of Biological Sciences, 15 14: 666-672. doi:10.3923/pjbs.2012.666.672


Author Kundu, N. Krishna
Obayed, Ullah M.
Hamid, Kaiser
Urmi, Kaniz Fatima
Bulbul, Israt Jahan
Khan, Muhammad Atikul Islam
Akter, Momita
Choudhuri, M. S. K.
Title Studies of lipid profile, liver function and kidney function parameters of rat plasma after chronic administration of "Sulavajrini Vatika"
Journal name Pakistan Journal of Biological Sciences   Check publisher's open access policy
ISSN 1028-8880
1812-5735
Publication date 2012
Sub-type Article (original research)
DOI 10.3923/pjbs.2012.666.672
Open Access Status DOI
Volume 15
Issue 14
Start page 666
End page 672
Total pages 7
Place of publication Faisalabad, Pakistan
Publisher A N S I Network
Language eng
Subject 1102 Cardiovascular Medicine and Haematology
Formatted abstract
The successful use of Ayurvedic medicines is for many years but there is no guideline for studying the toxicity of these preparations through preclinical or clinical investigations. The present study was conducted to evaluate the effect of conventionally prepared Sulavajrini Vatika (SBB), an Ayurvedic formulation on various biochemical parameters of experimental animals after chronic administration. The animal used was albino rats (Rattus norvegicus: Sprague-Dawley strain) and SBB was administered orally at a single dose of 100 mg kg-1 b.wt. day-1, up to 62 days. During the study, forty rats, equally of both sexes, were randomly grouped into four where one male and one female group were used as control and other groups were used as test. Among the lipid components, Triglyceride (TG) was decreased very high significantly in both sexes of animal. The decrease of Total Cholesterol (TC), Very Low Density Lipoprotein (VLDL) and high-density lipoprotein (HDL) were also highly significant. Low Density Lipoprotein (LDL) decreased in all SBB treated group. In the liver function parameters, the total protein and albumin content were increased very high significantly in both sexes of rat. But the bilirubin was decreased insignificantly in male and female rats. Serum Glutamic Pyruvic Transaminase (GPT), Glutamic Oxaloacetic Transaminase (GOT) and Alkaline Phosphatase (ALP) were decreased in all treated animals and it was very high significant. In case of kidney function parameters, creatinine was increased very high significantly but the urea was decreased very high significantly in both sexes of rat. The decrease in uric acid was not significant in none of the sexes of rat. The present study confirms that SBB can be contributory for the complications in diabetics with hyperlipidemia and nephropathy as it lowers most of the lipids components and improves liver function and kidney function parameters.
Keyword Sulavajrini Vatika
Ayurvedic
Lipid profile
Kidney function
Liver function
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Thu, 28 Nov 2013, 12:22:09 EST by System User on behalf of School of Chemistry & Molecular Biosciences