Hypoglycemic, hypolippidemic and antioxidant effects of leaves methanolic extract of Baccaurea ramiflora

Ullah, M. Obayed, Urmi, Kaniz Fatima, Howlader, Md. Amran, Hossain, Md. Kamal, Ahmed, Mohammad Towhir and Hamid, Kaiser (2012) Hypoglycemic, hypolippidemic and antioxidant effects of leaves methanolic extract of Baccaurea ramiflora. International Journal of Pharmacy and Pharmaceutical Sciences, 4 3: 266-269.

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Author Ullah, M. Obayed
Urmi, Kaniz Fatima
Howlader, Md. Amran
Hossain, Md. Kamal
Ahmed, Mohammad Towhir
Hamid, Kaiser
Title Hypoglycemic, hypolippidemic and antioxidant effects of leaves methanolic extract of Baccaurea ramiflora
Formatted title
Hypoglycemic, hypolippidemic and antioxidant effects of leaves methanolic extract of Baccaurea ramiflora
Journal name International Journal of Pharmacy and Pharmaceutical Sciences   Check publisher's open access policy
ISSN 0975-1491
Publication date 2012-07
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 4
Issue 3
Start page 266
End page 269
Total pages 4
Place of publication Sagar, Madhya Pradesh, India
Publisher International Journal of Pharmacy and Pharmaceutical Sciences
Language eng
Subject 3003 Pharmaceutical Science
3004 Pharmacology
Formatted abstract
The present study was designed for investigating the hypoglycemic, hypolipidemic and antioxidant activity of the leaves of B. ramiflora. Antioxidant potential was assayed by measuring the free radical scavenging activity using 1, 1-diphenyl-2-picrylhydrazyl (DPPH). Diabetes was induced in adult albino rats of both sexes by intra peritoneal (i.p) injection of alloxan (120 mg/kg). Methanolic extract of B. ramiflora leaves (200 mg/kg) was administered as a single dose per day to the diabetic rats for 14 days. The control group received distilled water for the same duration. Blood glucose levels and serum lipid profiles were measured in the diabetic and non‚Äźdiabetic rats. The methanolic extract showed potent free radical scavenging activity with IC50 value of 23.83 (μg/ml). It produced substantial hypoglycemia and reduced the elevated blood glucose level in the diabetic rats towards normal and it was statistically highly significant (p<0.005). Except HDL, the methanolic extract decreased the level of cholesterol, triglycerides and LDL and this reduction was statistically highly significant (p<0.005). The present study on this plant established that the leaves of B. ramiflora possess hypoglycemic, hypolipidemic and antioxidant activity.
Keyword B. ramiflora
Hypoglycemic
Hypolipidemic
Antioxidant
DPPH
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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