New factors contributing to dynamic calcium regulation in the skeletal muscle triad-a crowded place

Friedrich, Oliver, Fink, Rainer H. A. and von Wegner, Frederic (2010) New factors contributing to dynamic calcium regulation in the skeletal muscle triad-a crowded place. Biophysical Reviews, 2 1: 29-38. doi:10.1007/s12551-009-0027-2


Author Friedrich, Oliver
Fink, Rainer H. A.
von Wegner, Frederic
Title New factors contributing to dynamic calcium regulation in the skeletal muscle triad-a crowded place
Journal name Biophysical Reviews   Check publisher's open access policy
ISSN 1867-2450
1867-2469
Publication date 2010
Year available 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s12551-009-0027-2
Open Access Status File (Publisher version)
Volume 2
Issue 1
Start page 29
End page 38
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2010
Language eng
Subject 1304 Biophysics
1312 Molecular Biology
1315 Structural Biology
Abstract Skeletal muscle is a highly organized tissue that has to be optimized for fast signalling events conveying electrical excitation to contractile response. The site of electro-chemico-mechanical coupling is the skeletal muscle triad where two membrane systems, the extracellular t-tubules and the intracellular sarcoplasmic reticulum, come into very close contact. Structure fits function here and the signalling proteins DHPR and RyR1 were the first to be discovered to bridge this gap in a conformational coupling arrangement. Since then, however, new proteins and more signalling cascades have been identified just in the last decade, adding more diversity and fine tuning to the regulation of excitation-contraction coupling (ECC) and control over Ca2+ store content. The concept of Ca2+ entry into working skeletal muscle has become attractive again with the experimental evidence summarized in this review. Store-operated Ca2+ entry (SOCE), excitation-coupled Ca2+ entry (ECCE), action-potential-activated Ca2+ current (APACC), and retrograde EC-coupling (ECC) are new concepts additional to the conventional orthograde ECC; they have provided fascinating new insights into muscle physiology. In this review, we discuss the discovery of these pathways, their potential roles, and the signalling proteins involved that show that the triad may become a crowded place in time.
Keyword Action-potential activated Ca2+ entry
Retrograde coupling
Skeletal muscle
T system
Triad
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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