Vaccinating against influenza in children without needles: A new initiative

Kendall, Mark (2012) Vaccinating against influenza in children without needles: A new initiative. Journal of Pediatric Infectious Diseases, 7 2: 83-88. doi:10.3233/JPI-120349


Author Kendall, Mark
Title Vaccinating against influenza in children without needles: A new initiative
Journal name Journal of Pediatric Infectious Diseases   Check publisher's open access policy
ISSN 1305-7707
1305-7693
Publication date 2012-01-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3233/JPI-120349
Volume 7
Issue 2
Start page 83
End page 88
Total pages 6
Place of publication Amsterdam, The Netherlands
Publisher I O S Press
Collection year 2013
Language eng
Subject 2735 Pediatrics, Perinatology, and Child Health
2725 Infectious Diseases
Abstract Young children are of the highest hospital admission rate of all influenza cases. A broad and effective rollout of influenza vaccines for children is hindered by the current most common method of administration: the needle and syringe. Limitations include: reduced compliance due to needle-phobia; increased costs due to maintaining refrigeration due to transportation and storage (the cold chain); the need for qualified medical/nursing practitioners - to help reduce risk of unsafe injections and needle-stick injuries; and potentially impeded immunity - by delivery to muscle and not accessing the abundant antigen presenting cell populations resident in skin and mucosal surfaces. This paper explores needle-free routes to improved childhood influenza vaccines rollout, by being a practical device for self-Administration that has also generated significantly-improved immunogenicity and also the removal of the cold chain (through dry-formulation). Marketed devices targeting the mucosa through intranasal delivery (of liquid vaccine) are analysed, together with skin-targeting approaches currently in development - offering both improved immunogenicity and cold-chain removal by formulating the vaccine in a solid form.
Keyword Children
Vaccinating against influenza
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Australian Institute for Bioengineering and Nanotechnology Publications
 
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