Toxicological studies of Astavarga Kvatha Curna, an ayurvedic formulation, on liver function parameters of rat plasma

Hamid, K., Urmi, K. F., Kabir, M. S., Ullah, M. O. and Choudhuri, M. S. K. (2012) Toxicological studies of Astavarga Kvatha Curna, an ayurvedic formulation, on liver function parameters of rat plasma. Biology and Medicine, 4 1: 27-31. doi:10.4172/0974-8369.1000155

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Author Hamid, K.
Urmi, K. F.
Kabir, M. S.
Ullah, M. O.
Choudhuri, M. S. K.
Title Toxicological studies of Astavarga Kvatha Curna, an ayurvedic formulation, on liver function parameters of rat plasma
Journal name Biology and Medicine   Check publisher's open access policy
ISSN 0974-8369
Publication date 2012-01
Sub-type Article (original research)
DOI 10.4172/0974-8369.1000155
Open Access Status DOI
Volume 4
Issue 1
Start page 27
End page 31
Total pages 5
Place of publication Aligarh, India
Publisher E Business Navigators
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
Formatted abstract
Astavarga Kvatha Curna (AST) approved by the National Unani and Ayurvedic Formulary Committee of Bangladesh is widely used in the treatment of vata roga (neurological disorder) by the rural and ethnic people of this country. In the present study, the effect of this formulation on liver function parameters of rat plasma was examined after chronic administration. The animal used was albino rat (Rattus novergicus: Sprague-Dawley strains) and the drug was administered per oral route at a dose of 40 ml/kg body weight, once daily, up to 41 days for all the experiments. Forty rats, equally of both sexes, were randomly grouped into four where one male and one female group were used as control and other groups were used as test. In both male and female rats, there was a statistically significant increase in the total protein (male, p=0.044*, female, p=0.043)*. In case of albumin, the increase in the male rats were statistically significant (p=0.003)** but it was statistically highly significant (p=0.001)*** in the female rats. In case of sGOT, sGPT and ALP, there was a statistically highly significant (p=0.001)*** increase in both male and female rats. The level of bilirubin was decreased in both male and female rats and it was statistically highly significant (p=0.001)***.
Keyword Astavarga Kvatha Curna (AST)
Liver function parameters
Ayurvedic formulation
Rat plasma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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