Enrichment of cations via bipolar electrode focusing

Sheridan, Eoin, Hlushkou, Dzmitry, Knust, Kyle N., Tallarek, Ulrich and Crooks, Richard M. (2012) Enrichment of cations via bipolar electrode focusing. Analytical Chemistry, 84 17: 7393-7399. doi:10.1021/ac301101b


Author Sheridan, Eoin
Hlushkou, Dzmitry
Knust, Kyle N.
Tallarek, Ulrich
Crooks, Richard M.
Title Enrichment of cations via bipolar electrode focusing
Journal name Analytical Chemistry   Check publisher's open access policy
ISSN 0003-2700
1520-6882
Publication date 2012-09-04
Sub-type Article (original research)
DOI 10.1021/ac301101b
Volume 84
Issue 17
Start page 7393
End page 7399
Total pages 7
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Subject 1602 Criminology
Formatted abstract
We have previously demonstrated up to 5 × 10 5-fold enrichment of anionic analytes in a microchannel using a technique called bipolar electrode focusing (BEF). Here, we demonstrate that BEF can also be used to enrich a cationic fluorescent tracer. The important point is that chemical modification of the microchannel walls enables reversal of the electroosmotic flow (EOF), enabling cations, instead of anions, to be enriched via an electric field gradient focusing mechanism. Reversal of the EOF has significant consequences on the formation and shape of the region of the buffer solution depleted of charge carriers (depletion zone). Electric field measurements and numerical simulations are used to elucidate the factors influencing the depletion zone. This information is used to understand and control the location and shape of the depletion zone, which in turn influences the stability and concentration of the enriched band.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Mathematics and Physics
 
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