Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling

Alam, Md Ashraful, Uddin, Shaikh Jamal and Brown, Lindsay (2012) Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling. Studies in Natural Products Chemistry, 38 159-190. doi:10.1016/B978-0-444-59530-0.00006-X

Author Alam, Md Ashraful
Uddin, Shaikh Jamal
Brown, Lindsay
Title Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling
Journal name Studies in Natural Products Chemistry   Check publisher's open access policy
ISSN 1572-5995
Publication date 2012
Sub-type Article (original research)
DOI 10.1016/B978-0-444-59530-0.00006-X
Open Access Status
Volume 38
Start page 159
End page 190
Total pages 32
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Subject 1605 Policy and Administration
3002 Drug Discovery
Abstract Cellular responses require the activation of intracellular signal transduction pathways, particularly the activation of protein kinases. Mitogen-activated protein kinases (MAPKs) are responsible for a diverse range of physiological processes in cells including growth, survival, and apoptosis. Three different kinases, known as extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs), and p38 MAPKs, are activated by dual phosphorylation on both threonine and tyrosine residues within a Thr-Xaa-Tyr motif. JNKs and p38 MAPKs trigger apoptosis whereas ERKs are responsible for cellular survival in the presence of noxious stimuli. Intracellular stress mediated via free radical generation and other proinflammatory mediators may activate the MAPKs. Impaired G-protein-coupled receptor signaling, responsible for most of the complications associated with obesity and cardiovascular disorders, activates the MAPK pathway, which ultimately activates downstream transcription factors and gene expression related to cardiac growth. Polyphenolic compounds possessing strong antioxidant and antiinflammatory properties improve stress-activated disorders such as hypertension, atherosclerosis, cardiac hypertrophy, and remodeling. This review focuses on the underlying mechanisms of cardiac remodeling in oxidative stress and the therapeutic potential of natural compounds inhibiting MAPKs.
Keyword GPCR
Mitogen-activated protein kinase
Oxidative stress
Phenolic compounds
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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