Antioxidant, analgesic, cytotoxic and antidiarrheal activities of ethanolic Zizyphus mauritiana bark extract

Rahman, Shafiur (2012) Antioxidant, analgesic, cytotoxic and antidiarrheal activities of ethanolic Zizyphus mauritiana bark extract. Oriental Pharmacy and Experimental Medicine, 12 1: 67-73. doi:10.1007/s13596-011-0042-2


Author Rahman, Shafiur
Title Antioxidant, analgesic, cytotoxic and antidiarrheal activities of ethanolic Zizyphus mauritiana bark extract
Formatted title
Antioxidant, analgesic, cytotoxic and antidiarrheal activities of ethanolic Zizyphus mauritiana bark extract
Journal name Oriental Pharmacy and Experimental Medicine   Check publisher's open access policy
ISSN 1598-2386
2211-1069
Publication date 2012-03
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s13596-011-0042-2
Open Access Status
Volume 12
Issue 1
Start page 67
End page 73
Total pages 7
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Language eng
Subject 2707 Complementary and alternative medicine
Formatted abstract
The primary objective of this study was to investigate the pharmacological potential of the ethanolic extract of Zizyphus mauritiana bark. Antioxidant, analgesic, cytotoxic and antidiarrheal activities of the extract were investigated using 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay, acetic acid induced writhing inhibition, brine shrimp lethality bioassay and castor oil induced diarrhea inhibition respectively. The extract showed remarkable free radical scavenging activity with an IC50 of 27. 47 μg/mL. The extract produced significant (P < 0. 001) writhing inhibition at the doses of 250 mg and 500 mg/kg in acetic acid induced writhing in mice. With the extract, significant lethality to brine shrimp was found with LC 50 value at 92. 79 μg/mL. In antidiarrheal activity test, the extract produced 1. 25 h latent period of diarrheal induction and 75. 2% inhibition in diarrheal episodes compared to positive standard which showed 1. 3 h of latent period and 80. 55% inhibition in diarrheal episodes. Different phytoconstituents present in the bark might be responsible for biological activities found with this study. The results of this study support the traditional uses of this plant part and could form the basis of further investigation including compound isolation.
Keyword Zizyphus mauritiana
Antioxidant activity
Analgesic activity
Cytotoxic activity
Antidiarrheal activity
Medicinal plant
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
School of Pharmacy Publications
 
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