RNAi therapy: Involving the Immune System

McMillan, Nigel A. J. and Khairuddin, Norliana (2012) RNAi therapy: Involving the Immune System. International Drug Discovery, 2012 1: 14-17.

Author McMillan, Nigel A. J.
Khairuddin, Norliana
Title RNAi therapy: Involving the Immune System
Journal name International Drug Discovery   Check publisher's open access policy
ISSN 2150-4792
Publication date 2012
Year available 2012
Sub-type Article (original research)
Open Access Status
Volume 2012
Issue 1
Start page 14
End page 17
Total pages 4
Place of publication Indianapolis, IN United States
Publisher Russell Publishing LLC
Collection year 2012
Language eng
Subject 3002 Drug Discovery
Formatted abstract
 RNA interference (RNAi) is a powerful tool for gene silencing. Over the past decade our increased understanding of the molecular mechanisms underlying RNAi has provided an avenue towards utilizing it therapeutically. Of the many RNAi precursors, small interfering RNAs (siRNAs) have been the most successfully translated into the clinic. One of the major issues with RNA-based medicines is the cells’ ability to see and respond via pattern-recognition receptors such as Toll-like receptors (TLRs) and retinoic acid inducible gene 1 (RIG-1), inducing innate and adaptive immune responses. We propose that in certain diseases the combination of gene silencing and appropriate immune activation by so-called ‘bifunctional siRNA’ is a rational therapeutic approach and worthy of further investigation. Here we briefly review the progress in developing siRNA-based therapeutics and its interaction with the immune system, including siRNA design, types of immune activation, RNAi use in cancer and viral infections, as well as pre-clinical applications. We believe that development of immunostimulatory siRNAs provides the means for more potent therapies.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
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