The two-component histidine kinases DrkA and SlnA are required for in vivo growth in the human pathogen Penicillium marneffei

Boyce, Kylie J., Schreider, Lena, Kirszenblat, Leonie and Andrianopoulos, Alex (2011) The two-component histidine kinases DrkA and SlnA are required for in vivo growth in the human pathogen Penicillium marneffei. Molecular Microbiology, 82 5: 1164-1184. doi:10.1111/j.1365-2958.2011.07878.x


Author Boyce, Kylie J.
Schreider, Lena
Kirszenblat, Leonie
Andrianopoulos, Alex
Title The two-component histidine kinases DrkA and SlnA are required for in vivo growth in the human pathogen Penicillium marneffei
Formatted title
The two-component histidine kinases DrkA and SlnA are required for in vivo growth in the human pathogen Penicillium marneffei
Journal name Molecular Microbiology   Check publisher's open access policy
ISSN 0950-382X
1365-2958
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1111/j.1365-2958.2011.07878.x
Open Access Status
Volume 82
Issue 5
Start page 1164
End page 1184
Total pages 21
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Language eng
Formatted abstract
In order to cause disease fungal pathogens must be capable of evading or tolerating the host immune defence system. One commonly utilized evasion mechanism is the ability to continually reside within macrophages of the innate immune system and survive subsequent phagocytic destruction. For intracellular growth to occur, fungal pathogens which typically grow in a filamentous hyphal form in the environment must be able to switch growth to a unicellular yeast growth form in a process known as dimorphic switching. The cue to undergo dimorphic switching relies on the recognition of, and response to, the intracellular host environment. Two-component signalling systems are utilized by eukaryotes to sense and respond to changes in the external environment. This study has investigated the role of the hybrid histidine kinase components encoded by drkA and slnA, in the dimorphic pathogen Penicillium marneffei. Both SlnA and DrkA are required for stress adaptation but are uniquely required for different aspects of asexual development, hyphal morphogenesis and cell wall integrity. Importantly, slnA and drkA are both essential for the generation of yeast cells in vivo, with slnA required for the germination of conidia and drkA required for dimorphic switching during macrophage infection.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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