Familial recurrence risks for multiple sclerosis in Australia

O'Gorman, C., Freeman, S., Taylor, B. V., Butzkueven, H., Australian and New Zealand MS Genetics Consortium (ANZgene), Broadley S. A., Bahlo, M., Booth, D. R., Brown, M. A., Foote, S. J., Griffiths, L. R., Kilpatrick, T. J., Lechner-Scott, J., Moscato, P., Perreau, V. M., Scott, R. J., Stankovich, J., Stewart, G. J., Chapman, C., Marriot, M., Tanner, M., Tubridy, N. and Wiley, J. (2011) Familial recurrence risks for multiple sclerosis in Australia. Journal of Neurology, Neurosurgery and Psychiatry, 82 12: 1351-1354. doi:10.1136/jnnp.2010.233064


Author O'Gorman, C.
Freeman, S.
Taylor, B. V.
Butzkueven, H.
Australian and New Zealand MS Genetics Consortium (ANZgene)
Broadley S. A.
Bahlo, M.
Booth, D. R.
Brown, M. A.
Foote, S. J.
Griffiths, L. R.
Kilpatrick, T. J.
Lechner-Scott, J.
Moscato, P.
Perreau, V. M.
Scott, R. J.
Stankovich, J.
Stewart, G. J.
Chapman, C.
Marriot, M.
Tanner, M.
Tubridy, N.
Wiley, J.
Title Familial recurrence risks for multiple sclerosis in Australia
Journal name Journal of Neurology, Neurosurgery and Psychiatry   Check publisher's open access policy
ISSN 0022-3050
1468-330X
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1136/jnnp.2010.233064
Open Access Status
Volume 82
Issue 12
Start page 1351
End page 1354
Total pages 4
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Subject 2728 Clinical Neurology
2738 Psychiatry and Mental health
2746 Surgery
Formatted abstract
Background Genetic susceptibility to multiple sclerosis (MS) has been recognised for many years. Considerable data exist from the northern hemisphere regarding the familial recurrence risks for MS, but there are few data for the southern hemisphere and regions at lower latitude such as Australia. To investigate the interaction between environmental and genetic causative factors in MS, the authors undertook a familial recurrence risk study in three latitudinally distinct regions of Australia.

Methods Immediate and extended family pedigrees have been collected for three cohorts of people with MS in Queensland, Victoria and Tasmania spanning 15° of latitude. Age of onset data from Queensland were utilised to estimate age-adjusted recurrence rates.

Results Recurrence risks in Australia were significantly lower than in studies from northern hemisphere populations. The age-adjusted risk for siblings across Australia was 2.13% compared with 3.5% for the northern hemisphere. A similar pattern was seen for other relatives. The risks to relatives were proportional to the population risks for each site, and hence the sibling recurrence-risk ratio (λs) was similar across all sites.

Discussion The familial recurrence risk of MS in Australia is lower than in previously reported studies. This is directly related to the lower population prevalence of MS. The overall genetic susceptibility in Australia as measured by the λs is similar to the northern hemisphere, suggesting that the difference in population risk is explained largely by environmental factors rather than by genetic admixture.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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