Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin

Chen, X., Fernando, G. J. P., Corbett, H., Prow, T. W., Crichton, M. L. and Kendall, M. A. F. (2010). Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin. In: Andrew Dzurak, ICONN 2010 : 2010 International Conference on Nanoscience and Nanotechnology. 3rd International Conference on Nanoscience and Nanotechnology (ICONN) 2010, Sydney NSW Australia, (358-361). 22-26 February 2010. doi:10.1109/ICONN.2010.6045237


Author Chen, X.
Fernando, G. J. P.
Corbett, H.
Prow, T. W.
Crichton, M. L.
Kendall, M. A. F.
Title of paper Fast evaporation aided coating of densely packed and short microprojection patches for enhanced vaccine delivery to the skin
Conference name 3rd International Conference on Nanoscience and Nanotechnology (ICONN) 2010
Conference location Sydney NSW Australia
Conference dates 22-26 February 2010
Proceedings title ICONN 2010 : 2010 International Conference on Nanoscience and Nanotechnology
Journal name ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology
Place of Publication Piscatawa, NJ United States
Publisher I E E E
Publication Year 2010
Year available 2010
Sub-type Fully published paper
DOI 10.1109/ICONN.2010.6045237
ISBN 9781424452620
Editor Andrew Dzurak
Start page 358
End page 361
Total pages 4
Collection year 2011
Abstract/Summary We report a fast evaporation aided coating method to coat vaccines onto densely packed and very small microprojection containing patches which are used to efficiently deliver vaccines to the antigen presenting cells in the dermis/epidermis of the skin. Increased evaporation speed of coating solution aids localization of the vaccines on the distal tips of microprojections that penetrate into the skin; rather than to the backing and to the base of the microprojections. Therefore, the delivered efficiency of coated vaccine is increased. This method further improves the dose reduction effects we already observed with this novel patch design. This method of coating therefore will help to make more vaccine doses available in a case of a pandemic, help reduce the cost of the vaccines and provides a platform for future vaccines.
Subjects 1305 Biotechnology
1502 Banking, Finance and Investment
Keyword Delivery efficiency
Fast evaporation
Microprojections
Vaccine
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

 
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