Pain response in heroin users: personality, abstinence, and modulation by benzodiazepines

Ho, Ada Man Choi, Cheung, Ben Kin Leung and Stadlin, Alfreda (2011) Pain response in heroin users: personality, abstinence, and modulation by benzodiazepines. Addictive Behaviors, 36 12: 1361-1364. doi:10.1016/j.addbeh.2011.07.047

Author Ho, Ada Man Choi
Cheung, Ben Kin Leung
Stadlin, Alfreda
Title Pain response in heroin users: personality, abstinence, and modulation by benzodiazepines
Journal name Addictive Behaviors   Check publisher's open access policy
ISSN 0306-4603
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1016/j.addbeh.2011.07.047
Open Access Status
Volume 36
Issue 12
Start page 1361
End page 1364
Total pages 4
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Formatted abstract
We compared cold-pain responses among male current opioid users with and without concurrent benzodiazepine use, long-term ex-users, and healthy controls. Forty-eight current opioid users (14 concurrently using benzodiazepines), 34 ex-users (abstinent for ≥ 1y) and 63 controls received cold-pressor tests. Pain threshold (first reporting pain) and pain tolerance (total immersion time) were recorded. Pain thresholds were similar in ex-users and current users; pain tolerance was similar in ex-users and controls. Net pain tolerance (endurance) in ex-users was intermediate between the other two groups. Current users showed higher pain threshold and shorter pain tolerance than controls (p< 0.05). Current users not co-using benzodiazepines showed the lowest pain tolerance and net pain tolerance, and differed significantly from controls, ex-users, and current users co-using benzodiazepines (p< 0.05). Neuroticism was higher in current users than in the other two groups (p< 0.001), extraversion marginally lower (p< 0.05); net pain tolerance differences remained significant after controlling for these. Benzodiazepine use modulates pain tolerance in opioid users. Pain responses altered by opioid use may partially recover with abstinence.
Keyword Cold pressor test
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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