Hierarchy of immature hematopoietic cells related to blood flow and niche

Levesque, Jean-Pierre and Winkler, Ingrid G. (2011) Hierarchy of immature hematopoietic cells related to blood flow and niche. Current Opinion in Hematology, 18 4: 220-225. doi:10.1097/MOH.0b013e3283475fe7


Author Levesque, Jean-Pierre
Winkler, Ingrid G.
Title Hierarchy of immature hematopoietic cells related to blood flow and niche
Journal name Current Opinion in Hematology   Check publisher's open access policy
ISSN 1065-6251
1531-7048
Publication date 2011
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/MOH.0b013e3283475fe7
Open Access Status
Volume 18
Issue 4
Start page 220
End page 225
Total pages 6
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams and Wilkins
Collection year 2012
Language eng
Subject 2720 Hematology
Abstract Purpose of Review: Steady-state hematopoiesis in adult bone marrow requires the maintenance of a small pool of hematopoietic stem cells (HSCs) by self-renewing symmetric division. HSCs can be divided into potent rarely dividing HSCs which function as long-term reserve and more proliferative HSCs which contribute to maintaining the blood and immune cell pool. Extrinsic instructions provided by unique microenvironments (niches) regulate the fate of individual HSCs and progenitors. This review discusses the latest findings in respect to the organization and function of these niches. Recent Findings: It has recently emerged that mesenchymal stem cells, various osteoblastic progenitors and sinusoidal endothelial cells all critically regulate HSCs within niches. Each of these niche cells expresses different arrays of signaling proteins which differentially regulate HSCs and progenitors. HSCs have been reported in two types of niches. However, as osteoblastic/mesenchymal niches and perivascular niches overlap anatomically, this makes the dichotomy between osteoblastic niches for quiescent HSCs and endothelial niches for more proliferative HSCs a too simplistic model. Indeed local blood perfusion in a niche alone can functionally separate HSC populations. SUMMARY: The fate of each individual HSC is likely to be the result of the unique balance between signals elicited by proteins expressed by mesenchymal/osteoblastic progenitors, sinusoidal endothelial cells and physicochemical cues such as local blood perfusion and hypoxia in each individual niche. More sophisticated three-dimensional fluorescence microscopy techniques on whole mount bone fragments should provide new insights in the spatial organization of niches relative to bone and microcirculation in the bone marrow.
Keyword Hematopoietic stem cell
Hypoxia
Hypoxia inducible factor
Niche
Perfusion
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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