Palmitoylation pilots ras to recycling endosomes

Taguchi, Tomohiko and Misaki, Ryo (2011) Palmitoylation pilots ras to recycling endosomes. Small GTPases, 2 2: 82-84. doi:10.4161/sgtp.2.2.15245

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Author Taguchi, Tomohiko
Misaki, Ryo
Title Palmitoylation pilots ras to recycling endosomes
Journal name Small GTPases   Check publisher's open access policy
ISSN 2154-1248
2154-1256
Publication date 2011-03
Sub-type Article (original research)
DOI 10.4161/sgtp.2.2.15245
Open Access Status
Volume 2
Issue 2
Start page 82
End page 84
Total pages 3
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Language eng
Subject 1303 Specialist Studies in Education
1307 Cell Biology
Formatted abstract
We recently showed that palmitoylated Ras proteins (H-Ras and N-Ras) localize intracellularly at recycling endosomes (REs) and that REs act as a way-station for Ras proteins as they move along the post-Golgi exocytic pathway to the plasma membrane (PM). Palmitoylation is essential for H-Ras/N-Ras targeting to REs. H-Ras requires two palmitoyl groups for RE targeting. A lack of either or both palmitoyl groups causes H-Ras to be mislocalized to the endoplasmic reticulum (ER), the Golgi apparatus, or the PM. In this commentary, we summarize recent progress about the Ras trafficking cycle between the endomembranes (endosomes/ER/ Golgi) and the PM. We further discuss (1) the critical determinants of RE targeting of lipidated proteins and (2) possible Ras-mediated signaling pathways that originate from REs.
Keyword H-Ras
N-Ras
K-Ras
Rap2
Palmitoylation
Recycling endosomes
COS-1
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Wed, 27 Nov 2013, 20:14:07 EST by System User on behalf of Institute for Molecular Bioscience