Culture negative mitral valve endocarditis caused by Neisseria gonorrhoeae confirmed by 16S rDNA sequence analysis of resected valvular tissue

Butterly, Stuart J., Looke, David F. M., Byrne, Shane and Kaye, Gerry (2011) Culture negative mitral valve endocarditis caused by Neisseria gonorrhoeae confirmed by 16S rDNA sequence analysis of resected valvular tissue. Journal of Cardiology Cases, 3 2: e82-e85. doi:10.1016/j.jccase.2011.01.007


Author Butterly, Stuart J.
Looke, David F. M.
Byrne, Shane
Kaye, Gerry
Title Culture negative mitral valve endocarditis caused by Neisseria gonorrhoeae confirmed by 16S rDNA sequence analysis of resected valvular tissue
Formatted title
Culture negative mitral valve endocarditis caused by Neisseria gonorrhoeae confirmed by 16S rDNA sequence analysis of resected valvular tissue
Journal name Journal of Cardiology Cases   Check publisher's open access policy
ISSN 1878-5409
Publication date 2011-04
Sub-type Article (original research)
DOI 10.1016/j.jccase.2011.01.007
Open Access Status
Volume 3
Issue 2
Start page e82
End page e85
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Formatted abstract
Infective endocarditis is a dynamic disease with changing epidemiology and diagnostic strategies. Culture negative endocarditis poses a particular problem for clinicians regarding appropriate antimicrobial therapy and adequate duration of therapy. Utilization of nucleic acid amplification techniques and subsequent sequencing has provided clinicians an alternative to traditional phenotypic microbial identification which has been extremely useful in identification of fastidious organisms. We report a case of a young male with culture negative native mitral valve endocarditis and subsequent 16S rDNA sequencing of Neisseria gonorrhoeae from excised valvular tissue and embolic material. Identification of this organism with novel nucleic acid amplification and 16S rDNA sequence analysis techniques permitted targeted antibiotic therapy and successful treatment of this potentially fatal disease.
Keyword 16S DNA
Endocarditis
Neisseria gonorrhoeae
Polymerase chain reaction
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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