Silk fibroin in ocular tissue reconstruction

Harkin, Damien G., George, Karina A., Madden, Peter W., Schwab, Ivan R., Hutmacher, Dietmar W. and Chirila, Traian V. (2011) Silk fibroin in ocular tissue reconstruction. Biomaterials, 32 10: 2445-2458. doi:10.1016/j.biomaterials.2010.12.041

Author Harkin, Damien G.
George, Karina A.
Madden, Peter W.
Schwab, Ivan R.
Hutmacher, Dietmar W.
Chirila, Traian V.
Title Silk fibroin in ocular tissue reconstruction
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
Publication date 2011-04
Sub-type Article (original research)
DOI 10.1016/j.biomaterials.2010.12.041
Open Access Status
Volume 32
Issue 10
Start page 2445
End page 2458
Total pages 14
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
The silk structural protein fibroin displays potential for use in tissue engineering. We present here our opinion of its value as a biomaterial for reconstructing tissues of clinical significance within the human eye. We review the strengths and weaknesses of using fibroin in those parts of the eye that we believe are most amenable to cellular reconstruction, namely the corneoscleral limbus, corneal stroma, corneal endothelium and outer blood-retinal barrier (Ruysch's complex). In these areas we find that by employing the range of manufacturing products afforded by fibroin, relevant structural assemblies can be made for cells expanded ex vivo. Significant questions now need to be answered concerning the effect of this biomaterial on the phenotype of key cell types and the biocompatibility of fibroin within the eye. We conclude that fibroin's strength, structural versatility and potential for modification, combined with the relative simplicity of associated manufacturing processes, make fibroin a worthy candidate for further exploration.
Keyword Cornea
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Medicine Publications
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 43 times in Thomson Reuters Web of Science Article | Citations
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