ZnO and TiO(2) particles: a study on nanosafety and photoprotection

Popov, Alexey, Zhao, Xin, Zvyagin, Andrei, Lademann, Jürgen, Roberts, Michael, Sanchez, Washington, Priezzhev, Alexander and Myllylä, Risto (2010). ZnO and TiO(2) particles: a study on nanosafety and photoprotection. In: Jürgen Popp, Wolfgang Drexler, Valery V. Tuchin and Dennis L. Matthews, Biophotonics: Photonic Solutions for Better Health Care II. Proceedings of SPIE, v. 7715. SPIE Photonics Europe 2010. Biophotonics: Photonic Solutions for Better Health Care, Brussels, Belgium, (77153G.1-77153G.7). 12-16 April, 2010. doi:10.1117/12.854561


Author Popov, Alexey
Zhao, Xin
Zvyagin, Andrei
Lademann, Jürgen
Roberts, Michael
Sanchez, Washington
Priezzhev, Alexander
Myllylä, Risto
Title of paper ZnO and TiO(2) particles: a study on nanosafety and photoprotection
Formatted title
ZnO and TiO2 particles: a study on nanosafety and photoprotection
Conference name SPIE Photonics Europe 2010. Biophotonics: Photonic Solutions for Better Health Care
Conference location Brussels, Belgium
Conference dates 12-16 April, 2010
Proceedings title Biophotonics: Photonic Solutions for Better Health Care II. Proceedings of SPIE, v. 7715
Journal name Progress in Biomedical Optics and Imaging
Place of Publication Bellingham, WA, United States
Publisher S P I E - International Society for Optical Engineering
Publication Year 2010
Sub-type Fully published paper
DOI 10.1117/12.854561
ISBN 9780819481887
ISSN 1605-7422
Editor Jürgen Popp
Wolfgang Drexler
Valery V. Tuchin
Dennis L. Matthews
Volume 11
Issue 41
Start page 77153G.1
End page 77153G.7
Total pages 7
Language eng
Formatted Abstract/Summary
Nanoparticles of titanium dioxide (TiO2) and zinc oxide (ZnO) are used in sunscreens as protective compounds against UV radiation. We investigate these particles from the viewpoint of nanosafety (penetration into skin in vivo, production of free radicals when UV-irradiated) as well as UV protection. We show that: a) even after multiple applications, the particles remain within stratum corneum (uppermost skin layer); b) the optimal sizes are 62 nm and 45 nm, respectively for TiO2 and ZnO particles for 310-nm light and, correspondingly, 122 and 140 nm - for 400-nm radiation; c) in general, small particles (25 nm in diameter) are more photoactive than the larger ones (400 nm in diameter); however, on the background if porcine skin in vitro this difference is not seen and is substantially surpassed by skin contribution into production of free radicals.
Subjects 3107 Atomic and Molecular Physics, and Optics
2504 Electronic, Optical and Magnetic Materials
2502 Biomaterials
2741 Radiology Nuclear Medicine and imaging
Keyword Nanoparticles
TiO2
ZnO
UV light
Skin
Sunscreen
Phototoxicity
Nanosafety
TiO 2
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: School of Medicine Publications
 
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