The dawn of developmental signaling in the metazoa

Richards, G. S. and Degnan, B. M. (2009). The dawn of developmental signaling in the metazoa. In: Bruce Stillman, David J. Stewart and J. A. Witkowski, Evolution: The Molecular Landscape. 74th Cold Spring Harbor Symposia on Quantitative Biology, New York, (81-90). 27 May-1 June 2009. doi:10.1101/sqb.2009.74.028


Author Richards, G. S.
Degnan, B. M.
Title of paper The dawn of developmental signaling in the metazoa
Conference name 74th Cold Spring Harbor Symposia on Quantitative Biology
Conference location New York
Conference dates 27 May-1 June 2009
Proceedings title Evolution: The Molecular Landscape   Check publisher's open access policy
Journal name Cold Spring Harbor Symposia on Quantitative Biology   Check publisher's open access policy
Series Cold Spring Harbor symposia on quantitative biology (Series)
Place of Publication Woodbury, NY United States
Publisher Cold Spring Harbor Laboratory Press
Publication Year 2009
Year available 2009
Sub-type Fully published paper
DOI 10.1101/sqb.2009.74.028
ISBN 9780879698713
9780879698706
0879698705
ISSN 0091-7451
Editor Bruce Stillman
David J. Stewart
J. A. Witkowski
Volume 74
Start page 81
End page 90
Total pages 10
Collection year 2010
Language eng
Abstract/Summary Intercellular signaling underpins metazoan development by mediating the induction, organization, and cooperation of cells, tissues, and organs. Herein, the origins of the four major signaling pathways used during animal development and differentiation - Wnt, Notch, transforming growth factor-β (TGF-β), and Hedgehog - are assessed by comparative analysis of genomes from bilaterians, early branching metazoan phyla (poriferans, placozoans, and cnidarians), and the holozoan sister clade to the animal kingdom, the choanoflagellates. On the basis of the incidence and domain architectures of core pathway ligands, receptors, signal transducers, and transcription factors in representative species of these lineages, it appears that the Notch, Wnt, and TGF-β pathways are metazoan synapomorphies, whereas the Hedgehog pathway arose in the protoeumetazoan lineage, after its divergence from poriferan and placozoan lineages. Examination of the binding domains and motifs present in signaling pathway components of nonbilaterians reveals cases in which signaling interactions are unlikely to be operating in accordance with bilaterian canons. Overall, this study highlights the stability and antiquity of the core cytosolic components of each pathway, juxtaposed with the more variable and recently evolved molecular interactions taking place at the cell surface.
Subjects 1312 Molecular Biology
1311 Genetics
1303 Specialist Studies in Education
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: School of Biological Sciences Publications
 
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