Characterization of Cardiac Brain Natriuretic Peptide Release in Patients With Paroxysmal Atrial Fibrillation Undergoing Left Atrial Ablation

Gould, Paul A., Gula, L. J., Bhayana, V., Subbiah, R. N., Bentley, C., Yee, Raymond, Klein, George J., Krahn, Andrew D. and Skanes, Allan C. (2010) Characterization of Cardiac Brain Natriuretic Peptide Release in Patients With Paroxysmal Atrial Fibrillation Undergoing Left Atrial Ablation. Circulation-Arrhythmia and Electrophysiology, 3 1: 18-23. doi:10.1161/CIRCEP.108.831586


Author Gould, Paul A.
Gula, L. J.
Bhayana, V.
Subbiah, R. N.
Bentley, C.
Yee, Raymond
Klein, George J.
Krahn, Andrew D.
Skanes, Allan C.
Title Characterization of Cardiac Brain Natriuretic Peptide Release in Patients With Paroxysmal Atrial Fibrillation Undergoing Left Atrial Ablation
Journal name Circulation-Arrhythmia and Electrophysiology   Check publisher's open access policy
ISSN 1941-3149
1941-3084
Publication date 2010-02
Year available 2010
Sub-type Article (original research)
DOI 10.1161/CIRCEP.108.831586
Open Access Status
Volume 3
Issue 1
Start page 18
End page 23
Total pages 6
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams and Wilkins
Collection year 2010
Language eng
Formatted abstract
 Background— Paroxysmal atrial fibrillation (PAF) is associated with elevated levels of brain natriuretic peptide (BNP). The exact cardiac source and implications of this are currently unknown, as are the effects of left atrial ablation on cardiac BNP release. We sought to investigate BNP levels at different cardiac sites in PAF patients before and after left atrial ablation and compare these with a non–atrial fibrillation control cohort.

Methods and Results— Twenty PAF patients (52±10 years, 70% men; left ventricular ejection fraction, 55±3%) undergoing ablation were studied, BNP levels were measured at different cardiac sites before and after ablation and compared with a control cohort undergoing ablation for left lateral accessory pathways (10 patients, 41±11 years; left ventricular ejection fraction, 55±4%). In both cohorts, the coronary sinus BNP levels were the greatest. The PAF cohort had significantly greater BNP levels than the control cohort at all sites before and after ablation. Ablation of the left atrium was associated with a significant decrease in coronary sinus BNP levels (P=0.05) and transcardiac BNP gradient (P=0.03). This was not observed in the control cohort.

Conclusions— BNP levels are elevated in PAF, with the highest levels in the coronary sinus. Ablation of the left atrium was associated with an immediate decrease of BNP levels, implicating this as the source
Keyword Ablation
Atrium
Natriuretic Peptides
Pulmonary Vein Isolation
Heart failure
Catheter Ablation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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