Investigating the change of the hierarchical pattern of gene expression in the normal and Parkinson's brain using a combinatorial optimization based unsupervised clustering method

Hourani, Mou'ath, Mahata, Pritha and El Emary, Ibrahiem M. M. (2010) Investigating the change of the hierarchical pattern of gene expression in the normal and Parkinson's brain using a combinatorial optimization based unsupervised clustering method. UPB Scientific Bulletin, Series C: Electrical Engineering, 72 2: 141-160.

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Name Description MIMEType Size Downloads
Author Hourani, Mou'ath
Mahata, Pritha
El Emary, Ibrahiem M. M.
Title Investigating the change of the hierarchical pattern of gene expression in the normal and Parkinson's brain using a combinatorial optimization based unsupervised clustering method
Language of Title eng
Journal name UPB Scientific Bulletin, Series C: Electrical Engineering
Language of Journal Name eng
ISSN 1454-234X
2286-3559
Publication date 2010
Sub-type Article (original research)
Open Access Status
Volume 72
Issue 2
Start page 141
End page 160
Total pages 20
Place of publication Bucharest, Romania
Publisher Universitatea Politehnica din Bucuresti
Language eng
rum
Subject 2208 Electrical and Electronic Engineering
Formatted abstract
Previous works on Parkinson's disease (PD) mainly focused on genes differentially expressed between the anterior and the posterior sections of the brains of a normal mouse and the one with PD. However, no work has been done in finding a hierarchical pattern of gene expression between the different regions of a brain. Such a hierarchy is useful to locate genetic specializations within a normal brain, thus in analyzing how brain infirmities affect these specializations. We use a recently proposed method of robust hierarchical clustering using arithmetic-harmonic cut to construct the hierarchical relation between different regions of the brain. Then, we show how similar regions of the normal and PD brain differ in gene expressions, indicating a functional variation due to Parkinson's disease in a few high-level clusters of brain regions.
Keyword Parkinson's disease
Gene expression
Combinatorial optimization
Unsupervised clustering
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Information Technology and Electrical Engineering Publications
 
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Created: Wed, 27 Nov 2013, 12:07:04 EST by System User on behalf of School of Information Technol and Elec Engineering