Hierarchical assembly of hybrid nanoapatites: implications for oral drug delivery and implant-biological interfaces

Kasinath, Rajendra, Braizer, Allen, Prakash, Kithva Hariram and Gower, Laurie (2009). Hierarchical assembly of hybrid nanoapatites: implications for oral drug delivery and implant-biological interfaces. In: Tom Hinklin and Kathy Lu, Processing of Nanoparticle Structures and Composites: A Collection of Papers Presented at the 2008 Materials Science and Technology Conference (MS&T08). MS&T'08: Materials Science and Technology 2008 Conference and Exhibition, Pittsburgh, PA, USA, (123-132). 5-9 October, 2008. doi:10.1002/9780470551523.ch13


Author Kasinath, Rajendra
Braizer, Allen
Prakash, Kithva Hariram
Gower, Laurie
Title of paper Hierarchical assembly of hybrid nanoapatites: implications for oral drug delivery and implant-biological interfaces
Conference name MS&T'08: Materials Science and Technology 2008 Conference and Exhibition
Conference location Pittsburgh, PA, USA
Conference dates 5-9 October, 2008
Proceedings title Processing of Nanoparticle Structures and Composites: A Collection of Papers Presented at the 2008 Materials Science and Technology Conference (MS&T08)   Check publisher's open access policy
Journal name Ceramic Transactions   Check publisher's open access policy
Place of Publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Publication Year 2009
Year available 2008
Sub-type Fully published paper
DOI 10.1002/9780470551523.ch13
ISBN 9780470408469
9780470551523
ISSN 1042-1122
Editor Tom Hinklin
Kathy Lu
Volume 208
Start page 123
End page 132
Total pages 10
Language eng
Formatted Abstract/Summary
This work describes the modulation of crystallization and hierarchical structuring of hydroxyapatite-chitosan hybrid nano-particulates mediated by chitosan. Trace amounts of chitosan introduced at the onset of crystallization aided in the formation of assembled chains of equiaxed nano-HA with a narrow size distribution. Equiaxed nano-HA particles are not indicative of equilibrium morphology, as these crystals take on distinct acicular growth morphology along their c-axis typically exhibiting high aspect-ratio crystals. The highlight of this study, however, is that upon solvent extraction these hybrid suspensions form graded iridescent films which exhibited clear indications of assembly at multiple length scales: (1) below 50 nm, the ordering of nHA particles on self-assembled fibrils of chitosan was observed and (2) between 500-2000 nm, a higher order structure resembling a nano-porous sponge consisting of an interpenetrating composite of HA and chitosan was observed. The extent of assembly was dependent on the concentration of chitosan added during synthesis. The cross-section of the films revealed both structural and compositional grading with mainly chitosan on one surface and HA at the other. The implication of such hybrid nanostructures with multiple levels of structure, especially for drug delivery devices and implant-biological interfaces, is discussed further.
Subjects 2503 Ceramics and Composites
2505 Materials Chemistry
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

 
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