Comparative treatment and mortality correlates and adverse event profile of implant naltrexone and sublingual buprenorphine

Reece, Albert Stuart (2009) Comparative treatment and mortality correlates and adverse event profile of implant naltrexone and sublingual buprenorphine. Journal of Substance Abuse Treatment, 37 3: 256-265. doi:10.1016/j.jsat.2009.03.008


Author Reece, Albert Stuart
Title Comparative treatment and mortality correlates and adverse event profile of implant naltrexone and sublingual buprenorphine
Journal name Journal of Substance Abuse Treatment   Check publisher's open access policy
ISSN 0740-5472
1873-6483
Publication date 2009-10
Sub-type Article (original research)
DOI 10.1016/j.jsat.2009.03.008
Open Access Status
Volume 37
Issue 3
Start page 256
End page 265
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Formatted abstract
There is increasing interest in the use of implantable naltrexone as a new treatment for opiate dependence. This center has been one of the leaders in this form of treatment in Australia and has recently completed a registry-controlled review of our mortality data. As part of the study of the safety profile of this therapy, we were interested to review both the treatment correlates of previously presented mortality data and of adverse events. A total of 255 naltrexone implant therapy (NIT) and 2,518 buprenorphine (BUP) patients were followed for 1,322.22 and 8,030.02 patient-years, respectively. NIT patients had significantly longer days in treatment per episode (mean ± standard deviation, 238.32 ± 110.11 vs. 46.96 ± 109.79), total treatment duration (371.21 ± 284.64 vs. 162.50 ± 245.76), and mean treatment times but fewer treatment episodes than BUP (all p < .0001). Serious local tissue reaction or infection each occurred in 1% of 200 NIT episodes. These data show that NIT economizes treatment resources without compromising safety concerns.
Keyword Buprenorphine
Mortality
Naltrexone implants
Serious adverse events
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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