The role of novel biomarkers of cardiovascular disease in chronic kidney disease: Focus on adiponectin and leptin

Kaisar, Omar M., Johnson, David W., Prins, Judith B. and Isbel, Nicole (2008) The role of novel biomarkers of cardiovascular disease in chronic kidney disease: Focus on adiponectin and leptin. Current Cardiology Reviews, 4 4: 287-292. doi:10.2174/157340308786349516


Author Kaisar, Omar M.
Johnson, David W.
Prins, Judith B.
Isbel, Nicole
Title The role of novel biomarkers of cardiovascular disease in chronic kidney disease: Focus on adiponectin and leptin
Journal name Current Cardiology Reviews   Check publisher's open access policy
ISSN 1573-403X
1875-6557
Publication date 2008
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/157340308786349516
Open Access Status
Volume 4
Issue 4
Start page 287
End page 292
Total pages 6
Place of publication Bussum, The Netherlands
Publisher Bentham Science Publishers Ltd.
Collection year 2009
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Cardiovascular disease (CVD) remains a major cause of premature death in patients with chronic kidney disease (CKD), including renal transplant recipients. Both interplay of traditional cardiovascular and renal specific risk factors have been shown to be associated with an increased risk of cardiovascular death in patients with CKD. Recently, there has been great interest in the role of novel biomarkers, in particular adiponectin and leptin, and its association with CVD in the CKD population. Adiponectin is a multifunctional adipocyte-derived protein with anti-inflammatory, antiatherogenic and insulin sensitizing activity. Recent observational studies have shown adiponectin to be a novel risk marker of CVD in patients with stages 1 to 5 CKD. Leptin is an adipocyte-derived hormone that promotes weight loss by decreasing food intake. Similarly, there are observational studies to support an association between leptin and CVD, including patients with CKD. In the CKD population, leptin may be associated with uremic cachexia and subsequent increased mortality. This review aims to summarize the pathophysiological and potential clinical roles of these cardiovascular biomarkers in patients with CKD.
Keyword Adiponectin
Biomarker
Cardiovascular disease
Kidney disease
Leptin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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