Urological implications of cyclophosphamide and ifosfamide

Lawson, Malcolm, Vasilaras, Arthur, De Vries, Annamarie, Mactaggart, Peter and Nicol, David (2008) Urological implications of cyclophosphamide and ifosfamide. Scandinavian Journal of Urology and Nephrology, 42 4: 309-317. doi:10.1080/00365590701570953


Author Lawson, Malcolm
Vasilaras, Arthur
De Vries, Annamarie
Mactaggart, Peter
Nicol, David
Title Urological implications of cyclophosphamide and ifosfamide
Journal name Scandinavian Journal of Urology and Nephrology   Check publisher's open access policy
ISSN 0036-5599
1651-2065
Publication date 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/00365590701570953
Open Access Status
Volume 42
Issue 4
Start page 309
End page 317
Total pages 9
Place of publication London, United Kingdom
Publisher Informa Healthcare
Abstract Cyclophosphamide and ifosfamide are commonly used cytotoxic medications that are indicated in a wide range of conditions, both benign and malignant. Complications of their use include well-recognized acute and chronic urological side-effects. Haemorrhagic cystitis, nephrotoxicity and transitional cell carcinoma can be directly attributed to the use of these agents, and are potentially fatal. Preventive measures can be used in an attempt to minimize the rate of complications. Urological intervention may be required in the acute and long-term management of patients who have received oxazaphosphorine agents. This article reviews current literature, sourced using a MEDLINE search of the keywords with cross-referencing. All articles were reviewed by abstract. Selection of articles was on the basis of randomized controlled trials and articles adding new or significant information.
Keyword Cyclophosphamide
Haemorrhagic cystitis
Ifosfamide
Nephrotoxicit
Oxazaphosphorine
Transitional cell carcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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