Ethanol neurotoxicity and dentate gyrus development

Miki, Takanori, Yokoyama, Toshifumi, Sumitani, Kazunori, Kusaka, Takashi, Warita, Katsuhiko, Matsumoto, Yoshiki, Wang, Zhi-Yu, Wilce, Peter A., Bedi, Kuldip S., Itoh, Susumu and Takeuchi, Yoshiki (2008) Ethanol neurotoxicity and dentate gyrus development. Congenital Anomalies, 48 3: 110-117. doi:10.1111/j.1741-4520.2008.00190.x

Author Miki, Takanori
Yokoyama, Toshifumi
Sumitani, Kazunori
Kusaka, Takashi
Warita, Katsuhiko
Matsumoto, Yoshiki
Wang, Zhi-Yu
Wilce, Peter A.
Bedi, Kuldip S.
Itoh, Susumu
Takeuchi, Yoshiki
Title Ethanol neurotoxicity and dentate gyrus development
Journal name Congenital Anomalies   Check publisher's open access policy
ISSN 0914-3505
Publication date 2008-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1741-4520.2008.00190.x
Open Access Status
Volume 48
Issue 3
Start page 110
End page 117
Total pages 8
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing
Abstract Maternal alcohol ingestion during pregnancy adversely affects the developing fetus, often leading to fetal alcohol syndrome (FAS). One of the most severe consequences of FAS is brain damage that is manifested as cognitive, learning, and behavioral deficits. The hippocampus plays a crucial role in such abilities; it is also known as one of the brain regions most vulnerable to ethanol-induced neurotoxicity. Our recent studies using morphometric techniques have further shown that ethanol neurotoxicity appears to affect the development of the dentate gyrus in a region-specific manner; it was found that early postnatal ethanol exposure causes a transitory deficit in the hilus volume of the dentate gyrus. It is strongly speculated that such structural modifications, even transitory ones, appear to result in developmental abnormalities in the brain circuitry and lead to the learning disabilities observed in FAS children. Based on reports on possible factors deciding ethanol neurotoxicity to the brain, we review developmental neurotoxicity to the dentate gyrus of the hippocampal formation.
Keyword Dentate gyrus
Fetal alcohol syndrome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
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