Antiepileptic drugs as human teratogens

Eadie, Mervyn J. (2008) Antiepileptic drugs as human teratogens. Expert Opinion on Drug Safety, 7 2: 195-209. doi:10.1517/14740338.7.2.195


Author Eadie, Mervyn J.
Title Antiepileptic drugs as human teratogens
Journal name Expert Opinion on Drug Safety   Check publisher's open access policy
ISSN 1474-0338
1744-764X
Publication date 2008-03
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/14740338.7.2.195
Open Access Status
Volume 7
Issue 2
Start page 195
End page 209
Total pages 15
Place of publication London, United Kingdom
Publisher Informa Healthcare
Formatted abstract
Background: There is still uncertainty concerning the risk of fetal malformation associated with the intake of various individual antiepileptic drugs in pregnant women. Objective: To assess the better-quality available evidence concerning the fetal hazards from exposure to antiepileptic drug monotherapy during human pregnancy. Method: Examination of the available English language literature, particularly that dealing with individual antiepileptic drugs used in monotherapy, in the larger case series with better-quality internal comparison data. Conclusions: There is reasonable evidence that valproate is a significant teratogen during therapeutic use in women; the other older antiepileptic drugs (phenobarbitone, phenytoin, carbamazepine) probably have some teratogenic potential, but less than valproate; the situation regarding the more recently marketed antiepileptic drugs is not yet clear.
Keyword Antiepileptic drugs
Malformations
Pregnancy
Teratogenesis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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