Effect of Astragalus polysaccharides on Erythrocyte Immune Adherence of Chickens Inoculated with Infectious Bursal Disease Virus

LI H.-q., Lloyd R.-J. and WANG J.-d. (2007) Effect of Astragalus polysaccharides on Erythrocyte Immune Adherence of Chickens Inoculated with Infectious Bursal Disease Virus. Agricultural Sciences in China, 6 11: 1402-1408. doi:10.1016/S1671-2927(07)60190-4


Author LI H.-q.
Lloyd R.-J.
WANG J.-d.
Title Effect of Astragalus polysaccharides on Erythrocyte Immune Adherence of Chickens Inoculated with Infectious Bursal Disease Virus
Journal name Agricultural Sciences in China   Check publisher's open access policy
ISSN 1671-2927
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/S1671-2927(07)60190-4
Volume 6
Issue 11
Start page 1402
End page 1408
Total pages 7
Subject 1102 Cardiovascular Medicine and Haematology
1110 Nursing
Abstract Two hundred and forty specific pathogen free leghorn chickens were randomly divided into four groups and reared in isolated pens. The tested chickens were negative to infectious bursal disease virus (IBDV) at 25 d old. Group 1 was treated with saline, whereas Groups 2, 3, and 4 were inoculated with 0.3 mL IBDV suspension intranasally the next day. Groups 3 and 4 were also administered with Astragalus polysaccharides (APS) intramuscularly twice daily at 5 or 10 mg kg-1 BW, respectively, until 31 d old. The erythrocyte-C3b receptor rosette rate (E-C3bRR) and the erythrocyte-C3b immune complex rosette rate (E-ICRR) were measured at 25, 29, 32, 35, and 38 d old. The results showed that IBDV significantly reduced E-C3bRR and E-ICRR when compared with the control group (P < 0.05), while simultaneous administration of APS with IBDV maintained E-C3bRR at similar levels to the control group (P > 0.05) and increased E-ICRR when compared with the control group and the group non-treated with APS (P < 0.05). APS treatment reduced the morbidity and mortality of chickens inoculated with IBDV (P < 0.05). The results suggest that APS may enhance the immune adherence of chickens erythrocytes by affecting the activity and/or the number of complement receptors on the erythrocyte membrane. These findings can be beneficial in providing an understanding of the basic mechanisms required for the rational application of APS in modern medicine.
Keyword Astragalus polysaccharides
chicken
erythrocyte
herbal therapy
immune modulation
infectious bursal disease virus (IBDV)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 26 Nov 2013, 21:19:26 EST by System User