Genetic factors in the pathogenesis of CPPD crystal deposition disease

Couto A.R. and Brown M.A. (2007) Genetic factors in the pathogenesis of CPPD crystal deposition disease. Current Rheumatology Reports, 9 3: 231-236. doi:10.1007/s11926-007-0037-7


Author Couto A.R.
Brown M.A.
Title Genetic factors in the pathogenesis of CPPD crystal deposition disease
Journal name Current Rheumatology Reports   Check publisher's open access policy
ISSN 1523-3774
Publication date 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11926-007-0037-7
Volume 9
Issue 3
Start page 231
End page 236
Total pages 6
Subject 2745 Rheumatology
Abstract Crystal deposition is a very complex process ruled by numerous factors. A small but important proportion of cases of chondrocalcinosis are monogenic, and many of the genes involved have been identified. These genetic findings strongly point to control of the level of extracellular inorganic pyrophosphate as the primary mechanism for their association with either calcium pyrophosphate dihydrate or hydroxyapatite deposition. However, effects on extracellular inorganic pyrophosphate levels do not explain the mechanism of association in all of these monogenic diseases. Further, there are likely to be several as yet unidentified genes that are important in this common condition. This review highlights what genetic studies have demonstrated about the processes involved in these diverse but related disorders. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import
 
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Created: Tue, 26 Nov 2013, 18:59:45 EST by System User