Comparative mapping of sheep chromosome 2q

Van Stijn T.C., French M.C., Dodds K.G., McEwan J.C., Broad T.E., Womack J.E., Tisdall D.J. and Galloway S.M. (2007) Comparative mapping of sheep chromosome 2q. Cytogenetic and Genome Research, 116 1-2: 85-92. doi:10.1159/000097422

Author Van Stijn T.C.
French M.C.
Dodds K.G.
McEwan J.C.
Broad T.E.
Womack J.E.
Tisdall D.J.
Galloway S.M.
Title Comparative mapping of sheep chromosome 2q
Journal name Cytogenetic and Genome Research   Check publisher's open access policy
ISSN 1424-8581
Publication date 2007
Sub-type Article (original research)
DOI 10.1159/000097422
Volume 116
Issue 1-2
Start page 85
End page 92
Total pages 8
Subject 1307 Cell Biology
1311 Genetics
Abstract Sheep chromosome 2q (OAR2q), which is homologous with human chromosome 2q (HSA2q), and cattle chromosome 2 (BTA2), is known to contain several loci contributing to carcass traits. However, the chromosomal rearrangements differentiating these chromosomes among the three species have not yet been determined and thus precise correspondences between the locations of sheep and human genes are not known. Twenty-six genes from HSA2q (2q21.1→2q36) have been assigned to OAR2q by genetic linkage mapping to refine this area of the sheep genome. Seventy-six genes were initially selected from HSA2q. Sixty-eight percent of the PCR primer sets designed for these genes amplified successfully in sheep, and 34% amplified polymorphic products. Part of the proximal arm of OAR2q was found to be inverted compared with HSA2q. The breakpoint has been localised near the growth differentiation factor 8 gene (GDF8), spanning 380 kb between the positions of the hypothetical protein (FLJ20160) (HSA2:191008944-191075046) and glutaminase (GLS) (HSA2:191453847-191538510) (Build36.1). Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
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