Surgery for Crohn's disease and anti-TNF agents: the changing scenario

Sorrentino, Dario, Fogel, Sandy and Van den Bogaerde, Johan (2013) Surgery for Crohn's disease and anti-TNF agents: the changing scenario. Expert Review of Gastroenterology and Hepatology, 7 8: 689-700. doi:10.1586/17474124.2013.842895

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Author Sorrentino, Dario
Fogel, Sandy
Van den Bogaerde, Johan
Title Surgery for Crohn's disease and anti-TNF agents: the changing scenario
Journal name Expert Review of Gastroenterology and Hepatology   Check publisher's open access policy
ISSN 1747-4124
1747-4132
Publication date 2013-11
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1586/17474124.2013.842895
Open Access Status
Volume 7
Issue 8
Start page 689
End page 700
Total pages 12
Place of publication London, United Kingdom
Publisher Expert Reviews
Collection year 2014
Language eng
Abstract Surgery has been a mainstay of therapy for Crohn’s disease for a long time, essentially as a consequence of the fairly modest efficacy of traditional medications such as immunomodulators, antibiotics and 5-ASA, especially in severe cases. However, in the past decade and half, the advent of anti-TNF agents has greatly changed the medical approach to this disease and may modify its general management as well. Here, we have reviewed the current literature on incidence of surgery, timing of surgery and postoperative recurrence of Crohn’s disease before and after the advent of anti-TNF agents. In addition, we have reviewed the risk of perioperative complications in patients on anti-TNF agents before surgery. The data show that the use of these medications is changing or expecting to change shortly a number of surgical aspects of Crohn’s disease management.
Keyword Anti-TNF agents
Crohn's disease
Infliximab
Incidence of surgery
Perioperative complications
Postoperative recurrence
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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