Interaction effects of lead on bioavailability and pharmacokinetics of arsenic in the rat

Diacomanolis, Violet, Noller, Barry N. and Ng, Jack C. (2013) Interaction effects of lead on bioavailability and pharmacokinetics of arsenic in the rat. Environmental Geochemistry and Health, 35 6: 757-766. doi:10.1007/s10653-013-9527-x

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Author Diacomanolis, Violet
Noller, Barry N.
Ng, Jack C.
Title Interaction effects of lead on bioavailability and pharmacokinetics of arsenic in the rat
Journal name Environmental Geochemistry and Health   Check publisher's open access policy
ISSN 0269-4042
Publication date 2013-12
Sub-type Article (original research)
DOI 10.1007/s10653-013-9527-x
Open Access Status
Volume 35
Issue 6
Start page 757
End page 766
Total pages 10
Place of publication Dordrecht, Netherlands
Publisher Springer
Collection year 2014
Language eng
Abstract Arsenic (As) and lead (Pb) are common contaminants found in mine waste materials. For an evidence-based risk assessment, it is important to better understand the potential interaction of mixed contaminants; and this interaction study was investigated in an in vivo rat model. Following co-administration of a fixed dose of AsV as in sodium arsenate and different doses of Pb as lead acetate to Sprague-Dawley rats, blood arsenic concentration and bioavailability decreased. A decrease in As blood concentration when lead was co-administered was observed with increasing lead doses. Pharmacokinetic parameters for As in the blood showed faster absorption and elimination of this metalloid in the presence of Pb. The elimination half-life of As decreased from 67 days in As solo group to 27-30 with doses of Pb. Bioavailability of As was also decreased by 30-43 % in the presence of Pb. Decreased urinary excretion of Pb and tissue accumulation were also observed. It indicates lower absorption of As when co-administered with Pb. A probable explanation for these findings is that As co-administration with Pb could have resulted in the formation of less soluble lead arsenate. However, such an interaction between As and Pb could only explain about one-third of the variation when real mine waste materials containing both of these elements were administered to rats. This suggests that other effects from physical and chemical parameters could contribute to the bioavailability of arsenic in complex real environmental samples.
Keyword Arsenic
Mine waste
Mixed contaminants
Pharmacokinetic parameters
Interaction effect
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 1 June 2013.

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Created: Sun, 17 Nov 2013, 00:17:23 EST by System User on behalf of National Res Centre For Environmental Toxicology