The Toll and Imd pathways are not required for Wolbachia-mediated dengue virus interference

Rances, Edwige, Johnson, Travis K., Popovici, Jean, Iturbe-Ormaetxe, Inaki, Zakir, Tasnim, Warr, Coral G. and O'Neill, Scott L. (2013) The Toll and Imd pathways are not required for Wolbachia-mediated dengue virus interference. Journal of Virology, 87 21: 11945-11949. doi:10.1128/JVI.01522-13


Author Rances, Edwige
Johnson, Travis K.
Popovici, Jean
Iturbe-Ormaetxe, Inaki
Zakir, Tasnim
Warr, Coral G.
O'Neill, Scott L.
Title The Toll and Imd pathways are not required for Wolbachia-mediated dengue virus interference
Formatted title
The Toll and Imd pathways are not required for Wolbachia-mediated dengue virus interference
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1098-5514
Publication date 2013-11
Sub-type Article (original research)
DOI 10.1128/JVI.01522-13
Open Access Status DOI
Volume 87
Issue 21
Start page 11945
End page 11949
Total pages 5
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2014
Language eng
Formatted abstract
Wolbachia blocks dengue virus replication in Drosophila melanogaster as well as in Aedes aegypti. Using the Drosophila model and mutations in the Toll and Imd pathways, we showed that neither pathway is required for expression of the dengue virusblocking phenotype in the Drosophila host. This provides additional evidence that the mechanistic basis of Wolbachia-mediated dengue virus blocking in insects is more complex than simple priming of the host insect innate immune system.
Keyword Life-Shortening Wolbachia
Mosquito Aedes-Aegypti
Drosophila-Simulans
Populations
Incompatibility
Symbiont
Establishment
Transmission
Melanogaster
Transcripts
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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