Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle

Fortes, M. R. S., Kemper, K., Sasazaki, S., Reverter, A., Pryce, J. E., Barendse, W., Bunch, R., McCulloch, R., Harrison, B., Bolormaa, S., Zhang, Y. D., Hawken, R. J., Goddard, M. E. and Lehnert, S. A. (2013) Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle. Animal Genetics, 44 6: 636-647. doi:10.1111/age.12075


Author Fortes, M. R. S.
Kemper, K.
Sasazaki, S.
Reverter, A.
Pryce, J. E.
Barendse, W.
Bunch, R.
McCulloch, R.
Harrison, B.
Bolormaa, S.
Zhang, Y. D.
Hawken, R. J.
Goddard, M. E.
Lehnert, S. A.
Title Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle
Formatted title
Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle
Journal name Animal Genetics   Check publisher's open access policy
ISSN 0268-9146
1365-2052
Publication date 2013-12
Sub-type Article (original research)
DOI 10.1111/age.12075
Volume 44
Issue 6
Start page 636
End page 647
Total pages 12
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell
Collection year 2014
Language eng
Formatted abstract
A putative functional mutation (rs109231213) near PLAG1 (BTA14) associated with stature was studied in beef cattle. Data from 8199 Bos taurus, Bos indicus and Tropical Composite cattle were used to test the associations between rs109231213 and various phenotypes. Further, 23 496 SNPs located on BTA14 were tested for association with these phenotypes, both independently and fitted together with rs109231213. The C allele of rs109231213 significantly increased hip height, weight, net food intake, age at puberty in males and females and decreased IGF-I concentration in blood and fat depth. When rs109231213 was fitted as a fixed effect in the model, there was an overall reduction in associations between other SNPs and these traits but some SNPs remained associated (P < 10-4). Frequency of the mutant C allele of rs109231213 differed among B. indicus (0.52), B. taurus (0.96) and Tropical Composite (0.68). Most chromosomes carrying the C allele had the same surrounding 10 SNP haplotype, probably because the C allele was introgressed into Brahman from B. taurus cattle. A region of reduced heterozygosity surrounds the C allele; this is small in B. taurus but 20 Mb long in Brahmans, indicating recent and strong selection for the mutant allele. Thus, the C allele appears to mark a mutation that has been selected almost to fixation in the B. taurus breeds studied here and introduced into Brahman cattle during grading up and selected to a frequency of 0.52 despite its negative effects on fertility.
Keyword Bovine
Genome-wide association
High-density SNP chip
IGF-I
Stature and reproduction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2014 Collection
 
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