Non-coding RNAs in homeostasis, disease and stress responses: an evolutionary perspective

Amaral, Paulo P., Dinger, Marcel E. and Mattick, John S. (2013) Non-coding RNAs in homeostasis, disease and stress responses: an evolutionary perspective. Briefings in Functional Genomics, 12 3: 254-278. doi:10.1093/bfgp/elt016


Author Amaral, Paulo P.
Dinger, Marcel E.
Mattick, John S.
Title Non-coding RNAs in homeostasis, disease and stress responses: an evolutionary perspective
Journal name Briefings in Functional Genomics   Check publisher's open access policy
ISSN 2041-2649
2041-2657
Publication date 2013-05
Year available 2013
Sub-type Article (original research)
DOI 10.1093/bfgp/elt016
Volume 12
Issue 3
Start page 254
End page 278
Total pages 25
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2014
Language eng
Abstract Cells and organisms are subject to challenges and perturbations in their environment and physiology in all stages of life. The molecular response to such changes, including insulting conditions such as pathogen infections, involves coordinated modulation of gene expression programmes and has not only homeostatic but also ecological and evolutionary importance. Although attention has been primarily focused on signalling pathways and protein networks, non–coding RNAs (ncRNAs), which comprise a significant output of the genomes of prokaryotes and especially eukaryotes, are increasingly implicated in the molecular mechanisms of these responses. Long and short ncRNAs not only regulate development and cell physiology, they are also involved in disease states, including cancers, in host–pathogen interactions, and in a variety of stress responses. Indeed, regulatory RNAs are part of genetically encoded response networks and also underpin epigenetic processes, which are emerging as key mechanisms of adaptation and transgenerational inheritance. Here we present the growing evidence that ncRNAs are intrinsically involved in cellular and organismal adaptation processes, in both robustness and protection to stresses, as well as in mechanisms generating evolutionary change.
Keyword regulatory RNA
epigenetic inheritance
stress response
regulatory evolution
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
 
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