Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2

O'Donovan, M. C., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., Georgieva, L., Dwyer, S., Holmans, P., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H-T, Giegling, I., Hartmann, A. M., Moeller, H.-J., Morris, D. W., Shi, Y., Feng, G., Hoffmann, P., Propping, P., Vasilescu, C., Maier, W., Rietschel, M., Zammit, S., Schumacher, J., Quinn, E. M., Schulze, T. G., Iwata, N., Ikeda, M., Darvasi, A., Shifman, S., He, L., Duan, J., Sanders, A. R., Levinson, D. F., Adolfsson, R., Osby, U., Terenius, L., Jonsson, E. G., Cichon, S., Noethen, M. M., Gill, M., Corvin, A. P., Rujescu, D., Gejman, P. V., Kirov, G., Craddock, N., Williams, N. M., Owen, M. J., Molecular Genetics of Schizophrenia Collaboration and Mowry, B.J. (2008) Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular Psychiatry, 14 1: 30-36. doi:10.1038/mp.2008.108


Author O'Donovan, M. C.
Norton, N.
Williams, H.
Peirce, T.
Moskvina, V.
Nikolov, I.
Hamshere, M.
Carroll, L.
Georgieva, L.
Dwyer, S.
Holmans, P.
Marchini, J. L.
Spencer, C. C. A.
Howie, B.
Leung, H-T
Giegling, I.
Hartmann, A. M.
Moeller, H.-J.
Morris, D. W.
Shi, Y.
Feng, G.
Hoffmann, P.
Propping, P.
Vasilescu, C.
Maier, W.
Rietschel, M.
Zammit, S.
Schumacher, J.
Quinn, E. M.
Schulze, T. G.
Iwata, N.
Ikeda, M.
Darvasi, A.
Shifman, S.
He, L.
Duan, J.
Sanders, A. R.
Levinson, D. F.
Adolfsson, R.
Osby, U.
Terenius, L.
Jonsson, E. G.
Cichon, S.
Noethen, M. M.
Gill, M.
Corvin, A. P.
Rujescu, D.
Gejman, P. V.
Kirov, G.
Craddock, N.
Williams, N. M.
Owen, M. J.
Molecular Genetics of Schizophrenia Collaboration
Mowry, B.J.
Title Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
1476-5578
Publication date 2008-09
Sub-type Article (original research)
DOI 10.1038/mp.2008.108
Open Access Status
Volume 14
Issue 1
Start page 30
End page 36
Total pages 7
Place of publication London United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
We and others have previously reported linkage to schizophrenia on chromosome 10q25–q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide polymorphisms (SNPs) mapping to 10q25–q26 that had been typed in a genome-wide association study (GWAS) of schizophrenia (479 UK cases/2937 controls). SNPs with P<0.01 (n=40) were genotyped in an additional 163 UK cases and those markers that remained nominally significant at P<0.01 (n=22) were genotyped in replication samples from Ireland, Germany and Bulgaria consisting of a total of 1664 cases with schizophrenia and 3541 controls. Only one SNP, rs17101921, was nominally significant after meta-analyses across the replication samples and this was genotyped in an additional six samples from the United States/Australia, Germany, China, Japan, Israel and Sweden (n=5142 cases/6561 controls). Across all replication samples, the allele at rs17101921 that was associated in the GWAS showed evidence for association independent of the original data (OR 1.17 (95% CI 1.06–1.29), P=0.0009). The SNP maps 85 kb from the nearest gene encoding fibroblast growth factor receptor 2 (FGFR2) making this a potential susceptibility gene for schizophrenia.
Keyword Fgfr2
Schizophrenia
Genome-wide association study
Genome-wide association
Possible susceptibility locus
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
School of Medicine Publications
 
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