Nicotine effects on attentional reorienting in mid-age adults, and interactions with apolipoprotein E status

Evans, Simon, Dowell, Nicholas G., Tabet, Naji, Tofts, Paul S., King, Sarah L., Gray, Marcus and Rusted, Jennifer M. (2013) Nicotine effects on attentional reorienting in mid-age adults, and interactions with apolipoprotein E status. Journal of Psychopharmacology, 27 11: 1007-1014. doi:10.1177/0269881113499828


Author Evans, Simon
Dowell, Nicholas G.
Tabet, Naji
Tofts, Paul S.
King, Sarah L.
Gray, Marcus
Rusted, Jennifer M.
Title Nicotine effects on attentional reorienting in mid-age adults, and interactions with apolipoprotein E status
Journal name Journal of Psychopharmacology   Check publisher's open access policy
ISSN 0269-8811
1461-7285
Publication date 2013-11
Year available 2013
Sub-type Article (original research)
DOI 10.1177/0269881113499828
Open Access Status
Volume 27
Issue 11
Start page 1007
End page 1014
Total pages 8
Place of publication London, United Kingdom
Publisher Sage Publications Ltd.
Collection year 2014
Language eng
Formatted abstract
Nicotine has been shown to speed attentional reorienting in cued target detection tasks, and work in young adults suggest that individuals carrying the apolipoprotein E (APOE) e4 allele might show greater sensitivity to the cognitive effects of nicotine. The APOE e4 allele is associated with increased risk of Alzheimer's disease (AD), and increased sensitivity to nicotine might reflect early cholinergic differences that relate to an enhanced risk of AD. The aim of this study was to investigate effects of nicotine and APOE on attentional reorienting in mid-age participants. APOE e4 (e4+) were compared to non-APOE e4 (e4-) carriers, and functional magnetic resonance imaging (fMRI) data acquired. Neural data showed that nicotine effects, and the network involved in reorienting, was consistent with studies in young adults. Nicotine improved attentional reorienting at the trend level. Although there were no behavioural effects of genotype, genotype effects were present neurally: e4+ showed decreased extrastriate activation, and enhanced effects of nicotine on reorienting in right middle frontal regions. Drug by genotype interactions were present in hippocampal and anterior cingulate regions. These results are consistent with differential sensitivity to nicotine according to APOE status, possibly reflecting abnormal cholinergic function and accelerated cognitive ageing in mid-age e4+.
Keyword Alzheimer's disease
Imaging
Nicotine
Apolipoprotein E
Mild Cognitive Impairment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
Centre for Advanced Imaging Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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