Early life arsenic exposure and acute and long-term responses to influenza A infection in mice

Ramsey, Kathryn A., Foong, Rachel E., Sly, Peter D., Larcombe, Alexander N. and Zosky, Graeme R. (2013) Early life arsenic exposure and acute and long-term responses to influenza A infection in mice. Environmental Health Perspectives, 121 10: 1187-1193. doi:10.1289/ehp.1306748

Author Ramsey, Kathryn A.
Foong, Rachel E.
Sly, Peter D.
Larcombe, Alexander N.
Zosky, Graeme R.
Title Early life arsenic exposure and acute and long-term responses to influenza A infection in mice
Journal name Environmental Health Perspectives   Check publisher's open access policy
ISSN 0091-6765
Publication date 2013-10
Sub-type Article (original research)
DOI 10.1289/ehp.1306748
Open Access Status DOI
Volume 121
Issue 10
Start page 1187
End page 1193
Total pages 7
Place of publication Research Triangle Park, NC, United States
Publisher U.S. Department of Health and Human Services * National Institute of Environmental Health Sciences
Collection year 2014
Language eng
Formatted abstract
Background: Arsenic is a significant global environmental health problem. Exposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase the rates of bronchiectasis in early adulthood.

Objective: We aimed to determine if early life exposure to arsenic exacerbates the response to early life influenza infection in mice.

Methods: C57BL/6 mice were exposed to arsenic in utero and throughout postnatal life. At 1 week of age, a subgroup of mice were infected with influenza A. We then assessed the acute and long-term effects of arsenic exposure on viral clearance, inflammation, lung structure, and lung function.

Results: Early life arsenic exposure reduced the clearance of and exacerbated the inflammatory response to influenza A, and resulted in acute and long-term changes in lung mechanics and airway structure.

Conclusions: Increased susceptibility to respiratory infections combined with exaggerated inflammatory responses throughout early life may contribute to the development of bronchiectasis in arsenic-exposed populations.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Queensland Children's Medical Research Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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