Effects of Exercise and Lifestyle Intervention on Cardiovascular Function in CKD

Howden, Erin J., Leano, Rodel, Petchey, William, Coombes, Jeff S., Isbel, Nicole M. and Marwick, Thomas H. (2013) Effects of Exercise and Lifestyle Intervention on Cardiovascular Function in CKD. Clinical Journal of the American Society of Nephrology, 8 9: 1494-1501. doi:10.2215/CJN.10141012

Author Howden, Erin J.
Leano, Rodel
Petchey, William
Coombes, Jeff S.
Isbel, Nicole M.
Marwick, Thomas H.
Title Effects of Exercise and Lifestyle Intervention on Cardiovascular Function in CKD
Journal name Clinical Journal of the American Society of Nephrology   Check publisher's open access policy
ISSN 1555-9041
Publication date 2013-09
Year available 2013
Sub-type Article (original research)
DOI 10.2215/CJN.10141012
Volume 8
Issue 9
Start page 1494
End page 1501
Total pages 8
Place of publication Washington, DC United States
Publisher American Society of Nephrology
Collection year 2014
Language eng
Formatted abstract
Background and objectives CKD is associated with poor cardiorespiratory fitness (CRF). This predefined substudy determined the effect of exercise training and lifestyle intervention on CRF and explored the effect on cardiovascular risk factors and cardiac and vascular function.

Design, setting, participants, & measurements Between February 2008 and March 2010, 90 patients with stage 3-4 CKD were screened with an exercise stress echocardiogram before enrollment. Patients (n=83) were randomized to standard care (control) or lifestyle intervention. The lifestyle intervention included multidisciplinary care (CKD clinic), a lifestyle program, and aerobic and resistance exercise training for 12 months. CRF (peak VO2), left ventricular function, arterial stiffness, anthropometric, and biochemical data were collected at baseline and 12 months.

Results Ten percent of randomized patients had subclinical myocardial ischemia at screening and completed the study without incident. There was no baseline difference among 72 patients who completed follow-up (36 in the lifestyle intervention group and 36 in the control group). The intervention increased peak VO2 (2.860.7 ml/kg per minute versus 20.360.9 ml/kg per minute; P=0.004). There was small weight loss (21.864.2 kg versus 0.763.7 kg; P=0.02) but no change in BP or lipids. Diastolic function improved (increased e' of 0.7561.16 cm/s versus 20.4761.0 cm/s; P=0.001) but systolic function was well preserved and did not change. The change in arterial elastance was attenuated (0.1160.76 mmHg/ml versus 0.7660.96 mmHg/ml; P=0.01). D peak VO2 was associated with group allocation and improved body composition.

Conclusions Exercise training and lifestyle intervention in patients with CKD produces improvements in CRF, body composition, and diastolic function.
Keyword Chronic Kidney-Disease
Ventricular Diastolic Function
Uremic Cardiomyopathy
Arterial Stiffness
Ejection Fraction
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
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