Dynamic Causal Modelling of epileptic seizure propagation pathways: A combined EEG-fMRI study

Murta, Teresa, Leal, Alberto, Garrido, Marta I. and Figueiredo, Patricia (2012) Dynamic Causal Modelling of epileptic seizure propagation pathways: A combined EEG-fMRI study. Neuroimage, 62 3: 1634-1642. doi:10.1016/j.neuroimage.2012.05.053


Author Murta, Teresa
Leal, Alberto
Garrido, Marta I.
Figueiredo, Patricia
Title Dynamic Causal Modelling of epileptic seizure propagation pathways: A combined EEG-fMRI study
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2012-09
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2012.05.053
Open Access Status
Volume 62
Issue 3
Start page 1634
End page 1642
Total pages 9
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Collection year 2012
Language eng
Formatted abstract
 Simultaneous EEG–fMRI offers the possibility of non-invasively studying the spatiotemporal dynamics of epileptic activity propagation from the focus towards an extended brain network, through the identification of the haemodynamic correlates of ictal electrical discharges. In epilepsy associated with hypothalamic hamartomas (HH), seizures are known to originate in the HH but different propagation pathways have been proposed. Here, Dynamic Causal Modelling (DCM) was employed to estimate the seizure propagation pathway from fMRI data recorded in a HH patient, by testing a set of clinically plausible network connectivity models of discharge propagation. The model consistent with early propagation from the HH to the temporal–occipital lobe followed by the frontal lobe was selected as the most likely model to explain the data. Our results demonstrate the applicability of DCM to investigate patient-specific effective connectivity in epileptic networks identified with EEG–fMRI. In this way, it is possible to study the propagation pathway of seizure activity, which has potentially great impact in the decision of the surgical approach for epilepsy treatment.
Keyword Epilepsy
Seizure
Effective connectivity
Hypothalamic hamartoma
Gelastic Epilepsy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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